If you have read some of Lao Xu's answers and articles, I believe you have a certain understanding of the causes and treatment of hair loss. Then you should know that a bottle of shampoo has the function of preventing alopecia, and it should at least have the following functions:
① inhibiting DHT
② sterilizing and anti-inflammatory
③ balancing the scalp environment and reducing the stimulation to hair follicles
④ promoting scalp blood circulation
⑤ containing some special ingredients to promote hair growth
The actual situation is that the shampoo on the market now can have.
bactericidal and anti-inflammatory shampoos
The principle of preventing alopecia in this kind of shampoos is to add anti-inflammatory and bactericidal chemicals to eliminate scalp inflammation. And most of them are OTC drugs, and there is no doubt about the effect, because most people with hair loss have scalp inflammation. On the other hand, if your hair has no inflammation and bacteria, but only androgen loss, then these shampoos can't help.
Common professional-grade bactericidal and anti-inflammatory shampoos include:
Ketoconazole lotion. OTC drug, the safest and most effective bactericidal lotion at present, can kill Malassezia, so it can be used to treat dandruff clinically. The common products are Kangwang and Caile, and the famous Renshan Lishu lotion abroad.
coal tar lotion. It has good bactericidal and anti-inflammatory ability, and also has the function of regulating epidermal cells, which has a good improvement effect on seborrheic dermatitis.
salicylic acid lotion. Salicylic acid is a relative of aspirin, which has a first-class bactericidal effect and a certain fat solubility. It is also used for scalp oil control. At present, there is a 3% concentration salicylic acid shampoo on the market.
In most cases, these shampoos are enough to solve the problem of scalp inflammation. If there are more serious problems of dermatitis and seborrhea, you should go to a regular dermatological hospital for treatment.
Specially added shampoos
This kind of shampoos can prevent hair loss: adding certain nutrients or special ingredients can promote hair growth. We all know that skin is an organ that can absorb and collect nutrients, so no matter what ingredients you add to your shampoo, it can be absorbed by the scalp and play its due role.
vitamin shampoo. Generally, B vitamins are added. As we all know, B vitamins are the most relevant vitamins for hair growth, and they are water-soluble, which means that they can be dissolved in shampoo, and can be absorbed locally to play its role.
saw palm shampoo. Saw palmetto is called "plant finasteride". If this ingredient is added to shampoo, it can theoretically reduce the DHT level, although the effect may be small.
adenosine. Japan's Shiseido once launched Adenovital shampoo, the main ingredient of which is Adenosine adenosine. This ingredient is considered to have a hair growth effect similar to minoxidil, and there are many medical papers supporting its hair growth ability, which is a relatively effective anti-hair loss product.
anti-androgen shampoo
The principle of hair loss prevention of this kind of shampoo is to reduce the influence of DHT on hair follicles and reduce hair loss. Smart friends must know that if a shampoo can reduce the effect of DHT on hair follicles, then the anti-hair loss effect of this shampoo will definitely be immediate, but unfortunately, this kind of shampoo is rare.
At present, the shampoo with caffeine formula has a certain theoretical basis.
In 213, Nanjing Medical University conducted a famous study called "Study on the Mechanism of Caffeine's Anti-Androgen Effect in Human Hair Papillary Cells Cultured in Vitro", which was published in the Journal of Clinical Dermatology. In this study, human dermal papilla cells were cultured in vitro under the environment of .5% caffeine and 1nmol/L testosterone, and finally the specific effect of caffeine on the growth and differentiation of dermal papilla in androgen environment was observed. Advanced observation methods such as AKP staining were used.
Studies have shown that caffeine can resist the damage of androgen (testosterone) to dermal papilla and promote hair growth.
effects of caffeine and testosterone on the growth of DPC at the top of the head (APK staining ×1)
effects of caffeine and testosterone on the proliferation of DPC at different parts
effects of caffeine and testosterone on the apoptosis of DPC at different parts
Studies show that hair follicles at the top of the head are most susceptible to testosterone and lose their germinal ability, and caffeine can greatly improve this problem and promote the continuous differentiation of hair follicles. For different parts of hair follicles, caffeine can reduce the probability of papilla death, but the top hair follicle is still the most susceptible to androgen and apoptosis, and caffeine can reduce this process. In addition, the posterior occipital hair follicle and pudendal hair follicle are not affected by androgen, which is also in line with our cognition.
So the conclusion is:
①.5% caffeine can promote the proliferation of dermal papilla and promote hair growth
②.5% caffeine can inhibit the cell death of dermal papilla and prolong the hair growth cycle. That is, .5% caffeine can play an anti-androgen alopecia role.
In further study, it was found that caffeine could inhibit the expression of SRD5A2 (similar to 5α reductase) and reduce the concentration of DHT. Many foreign studies also agree with the effect of caffeine in treating alopecia. One foreign study shows that .2% caffeine solution is more effective in treating male alopecia than 5% minoxidil. This study was published in Skin Pharmacol Physiol, which has certain authority.
it may be because this research has a certain knowledge all over the world. At present, there are many caffeine-containing anti-alopecia shampoos, such as Alpecin C1 in Germany, Ultrax Labs caffeine shampoo in the United States, and Grow Gorgeous caffeine shampoo. However, the effect of caffeine culture on dermal papilla in vitro does not mean that topical caffeine solution has a clear hair growth effect, and it does not mean that drinking more coffee can prevent hair loss, which are two different things. At present, we only see the great value of caffeine in preventing hair loss, and its actual effect needs to be further confirmed.
Finally, I would like to say some simple thoughts:
In fact, since ancient times, human beings have only one demand for "washing their hair"-cleanliness.
Gleditsia sinensis, Platycladus orientalis leaves, plant ash, etc., handed down from our ancestors, only achieved the functions of cleaning, sterilization and degreasing. It has little effect on the treatment of alopecia, because the former is only a daily chemical product, and alopecia is a disease, and it is a chronic disease. It is impossible to treat it simply with shampoo. However, anti-hair loss shampoo still has its own value. On the one hand, high-end anti-hair loss shampoo itself is a gentler and more comfortable choice. On the other hand, the research and development of various anti-hair loss patents does bring potential to promote hair growth.