It is an article or a book entitled "Crystal Changes and Crystal Addiction of Drugs and Their Important Effects on Drug Quality and Clinical Efficacy" in Foreign Medicine and Pharmacy, Volume 1980, No.04. tingzai0 1 16 (TA in Contact Station) has the following crystal forms:
Type a (? 8? Type 5): the stable type is not easily hydrolyzed by esterase in the intestine, is not easily absorbed and has low biological activity.
Type b (? 8? Type 4): Metastable state is easy to be hydrolyzed by esterase, the dissolution rate is faster than that of type A, it is easy to be absorbed, the blood concentration is 7 times that of type A, and the curative effect is high.
Type C: unstable type, which can be converted into type A. The crystalline form of Xiaohaojydl (in-station contact with TA) has great influence on drug absorption and metabolism. In addition, the patented crystal form is protected and needs to be avoided. Solid, insoluble and oral drugs need to be studied in crystalline form. Cyj 10 15 (TA in contact station) cimetidine
It is reported that crystal form A and crystal form AB are quite different in absorption in vivo. Clinically, crystal form A (USP is crystal form A) hcxcjw (in-station contact TA) is generally used to recommend you a relatively easy-to-use drug crystal form research instrument. Dutch Crystal 16 parallel crystallization instrument, represented by Liyang Enterprise Co., Ltd., can measure solubility curve and metastable zone width, and can also be used for polymorphic screening, * * crystallization research and anti-solvent crystallization.
The polymorph of Chenpi 886 (in-station contact with ta) has different physical and chemical properties, such as melting point, chemical reactivity and apparent solubility.
10, solubility, optical and mechanical properties, vapor pressure and density. These properties will directly affect drugs.
Quality and preparation production and technology, as well as the stability, dissolution and bioavailability of the drug. Therefore, polycrystalline
This phenomenon will affect the quality, safety and effectiveness of drugs. The solid nature of API will have an important influence on its apparent solubility. Polymorphs have different internal solid structures, so the water solubility and dissolution of different polymorphic drugs are different. If the apparent solubility of different polymorphs is different, we suggest paying attention to its potential impact on the bioavailability and bioequivalence of the preparation.