CHO and mrna have the following differences.
1. The recombinant new coronavirus vaccine (CHO cells) is a recombinant subunit vaccine without viral nucleic acid components. It targets the receptor binding domain (RBD) of the new coronavirus S protein and is expressed through recombinant RBD protein induces the body to produce neutralizing antibodies, thereby blocking the binding of the new coronavirus to the host cell surface receptor ACE2.
2. mRNA is a naturally occurring molecule that carries the blueprint of human cells and can produce target proteins or immunogens and activate immune responses in the body to fight various pathogens. The mRNA vaccine uses the genetic sequence of the virus rather than the virus itself. Therefore, the mRNA vaccine does not contain viral components and has no risk of infection.