Besides radiotherapy and chemotherapy, are there other ways to destroy tumor tissue? Researchers from Institute of Genetics and Developmental Biology, Chinese Academy of Sciences designed and synthesized a new type of nano luminescent material-gold nanoclusters with dihydrolipoic acid as ligand. Two-photon dynamic therapy based on this gold nanocluster has a good clinical transformation prospect in tumor treatment, especially in the treatment of glioma and solid tumor. Related research results have been applied for two invention patents, and recently published online in ACS Nano, the top international nanotechnology journal.
Photodynamic therapy of tumor is to use photosensitizer targeted at tumor to generate a large number of reactive oxygen radicals under laser irradiation and destroy tumor tissue. Compared with conventional tumor treatment methods such as radiotherapy and chemotherapy, photodynamic therapy has the characteristics of high spatial selectivity, low drug resistance and low systemic toxicity, and has been widely used in the treatment of esophageal cancer, bladder cancer, skin cancer and other cancers in recent years. The performance of photosensitizer is the key to determine the effect of photodynamic therapy. At present, the photosensitizer used in clinic is excited by visible light, which has a small tissue penetration depth and is difficult to be used for the treatment of solid tumors and deep tumors. Moreover, patients need weeks of darkness after treatment, which brings great inconvenience to life.
"In recent years, a new generation of two-photon photodynamic therapy excited by long waves has developed rapidly. However, the current lack of matching two-photon photosensitizers greatly limits clinical application. " Yu Qiang, a researcher at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, said.
He said that the research, design and synthesis of new materials have strong characteristics of generating free radicals under illumination, and have a very good killing effect on tumor cells and tissues. It is an excellent photosensitizer for photodynamic therapy, and its clinical effect is far better than Ella photosensitizer.
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