Inventor of azvudine

Chang Junbiao, male,1born in June 1965, was born in hua county, Henan Province. 1986 graduated from chemistry department of Henan university, 1989 graduated from Zhengzhou university of science and technology in China with a master's degree; 1996, Ph.D. candidate of Peking Union Medical College, 1996- 1998, postdoctoral fellow of the University of Georgia, USA; From 2000 to 2002, Novartis Institute of Genetics (G. Stork Fund) visited scientists. He is currently vice president of Zhengzhou University, adjunct professor of University of Science and Technology of China, doctoral supervisor, adjunct professor of Tianjin University, doctoral supervisor, member of National Pharmacopoeia Committee, director of Henan Key Laboratory of Fine Chemical Industry, and director of Henan Analytical Testing Center.

Engaged in organic chemistry and medicinal chemistry research, the research direction is the synthesis of antiviral drugs (hepatitis B and AIDS), and successively presided over the National Science Foundation for Distinguished Young Scholars, the National Natural Science Foundation and the National Key Basic Research and Development Plan (973 Plan); National high-tech research and development plan (863 plan); National major new drug project; National Ministry of Education's Support Program for Outstanding Talents in the New Century. "Study on the Total Synthesis of Schisandrin A and Schisandrin B, the effective components of traditional Chinese medicine Schisandra chinensis", which is the first time in the world to biomimetically synthesize the same pharmacological active products as natural Schisandrin A and Schisandrin B, has a good development prospect; Aiming at a series of compounds whose receptor structures are unknown and close to effective, a series of new nucleoside compounds were synthesized by computer-aided analysis of molecular pharmacophore and its conformation Pharmacological screening and animal experiments show that some compounds have high anti-AIDS activity and little toxic and side effects. Won the second prize of National Science and Technology Progress Award1as the project host; In 2006, he won the first prize of scientific and technological progress in Henan Province and the second prize of scientific and technological progress in Henan Province. 5 third prizes; Obtained 2 American invention patents; China has 18 national invention patents, which have produced remarkable social and economic benefits. Apply for 2 international invention patents; Apply for China invention patent16; In the internationally renowned journal Nature; Science; Published 160 papers and 7 academic monographs in the journal of Chemistry. Rev and China. Trained 16 doctoral students and 46 master students.

Honorary title: 1998 won the title of "Young and middle-aged expert with outstanding national contribution"; 1999 enjoy the special government allowance of the State Council; In 2004, he was awarded the "National Candidate for the New Century Million Talents Project"; Winner of "Central Plains Scholar" in Henan Province in 2008.