2. Zhang Quan, Zhai Jiawei,,, Zhang. China patent: Michelin lactone derivative, its pharmaceutical composition, its preparation method and use, (20 10).
3. Long Shoujiang, Zhai Jiadai, Zhang,,. China patent: preparation method of parthenolide, (20 10).
4. Sang Feng, Duan Xiyan, Zhai Jiadai, Li, Zhang Bin. China patent: epothilone analog, preparation method, pharmaceutical composition and use, (20 10) (authorization, authorization announcementNo. CN 10 1973987B, authorization announcement date.
5. Lu Yaxin, Chen Yue, Zhang Quan, Zhai Jiade China Patent: Michelin lactone lipid microsphere injection and its preparation method, (20 10).
6. Chen Yue, Zhang Quan, Qiu Chuanjiang and Qi Yanguo. China patent: preparation method of pyrrolidine 5- substituted pentadiene amide compounds, (20 10).
7. Chen Yue, Zhang Quan, Lu Yaxin, Ding Yahui, Zhai Jiawei, Ma Weiwei, Fan Hongxia, Zhang Haoliang and Wang Miao. China patent: Michelin lactone and its derivatives are used to treat cancer, (20 10) (authorized, authorization announcementNo. CN 10 1978959B, date of authorization announcement.
Chen Yue, Zhang Quan, Lu Yaxin, Zhai Jiawei, Ma Weiwei, Ding Yahui, Fan Hongxia, Zhang Haoliang and Wang Miao. China patent: application of Michelin lactone and its derivatives in the treatment of hepatitis C, (20 10) (authorized, with the authorization announcement number of CN 10 19665438+.
9. Patent of Zhang Quan, Chen Yue, Fan Hongxia, Long Jing and Zhai Jiadai in China: Method for preparing parthenolide from Magnolia Officinalis, Magnolia Officinalis and Magnolia Officinalis, (20 1 1).
10. Chen Yue, Zhang Quan, Lu Yaxin, Zhai Jiadai, Ding Yahui, Long Jing, Fan Hongxia, Zhang Haoliang, Wang Miao, Ma Weiwei. World patent: preparation method and application of Michelin lactone, (20 1 1).
1 1. Chen Yue, Zhang Quan, Lu Yaxin, Zhai Jiadai, Ding Yahui, Long Jing, Fan Hongxia, Zhang Haoliang, Wang Miao, Ma Wei. World patent: Michelin lactone derivative, its pharmaceutical composition, its preparation method and use, (20 1 1).
12. Chen Yue, Zhang Quan, Long Jing, Ding Yahui, Ma Weiwei, Zhai Jiawei, Fan Hongxia, Sun Lin. China patent: dehydrocostunolide derivative, its pharmaceutical composition, its preparation method and application, (20 1 1).
13. Duan Xiyan,,, stone,. China patent: triazole epothilone analogues, their pharmaceutical compositions, their preparation methods and uses, (20 12).
14. Chen Yue; Zhang quan; Zhai jiadai; Zhang Haoliang; Qiu Chuanjiang. China patent preparation method: Arglabin, application number: (20 12).
15. Chen Yue; Zhang quan; Dragon crystal; Han Bin; Ma Xiaoyan. China patent: costunolide derivatives, their pharmaceutical compositions, preparation methods and uses, (20 12).
16. Chen Yue; Zhang quan; Dragon crystal; Ma Weiwei; Zhai jiadai; Yang xiudong; Fan Hongxia; Ding Yahui; Wang Liang; Han Bin; Ma Xiaoyan; Zhang Haoliang; Qiu Chuanjiang. China patent: application of sesquiterpene lactone and its derivatives in preparation of drugs, (20 12).
17. Chen Yue, Zhang Quan, Long Jing, Yang Xiudong, Ding Yahui, Fan Hongxia, Han Bin, Ma Xiaoyan, Wang Liang, Zhang Haoliang. World patent: dehydrocostunolide derivatives, their pharmaceutical compositions, their preparation methods and uses, (20 12).
18. Chen Yue; Li Yong. Method for preparing epothilone, published date: 2008- 1 1-20. Also published as: US2009076289 and US2008319211.
19. Chen Yue; Li Yong. Intermediate and method for preparing epothilone, published on May 22, 2009.
Chen Yue; Li Yong; Lori Bruno; Puente Kurt; Method for preparing epothilone precursor compounds, published on September-17, 2009. (The synthetic routes of the above three world or American patents have been used in mass production or scale-up experiments of phase II clinical drugs, making the company in a leading position in the world in the total synthesis of epothilone drugs).
2 1. Taylor Richard e. Chen Yue. Derivatives of epothilone B and D and their synthesis, published on September 9, 2003-12, also published as US690033 1, AU20032 12457.
22. Fu Hong; Chen Yue; Santi Daniel v. Macrocyclic kinase inhibitor, published on: 2007- 1 1-22. Also published as: US2007265333, EP20 15745, NO20084583.
23. Liu Yaoquan; Carreras Christopher; Miles David C.; Li Yong; Shaw Simon James; Fu Hong; Chen Yue; Zheng Hao; Li Yandong; Burlingame mark a modi Park Jung Su compound, published on: 2006- 1 1-30. Also published as: US20062706 16, NO20076464, MX20070 14255, KR200800 13922, JP2008542268.