Brief history of blood cell analyzer development

1947 American scientist W.H.Coulter invented the patented technology of counting particles by resistance method. 1956, he successfully applied this technique to blood cell counting. Its principle is to count and measure blood cells based on the non-conductive characteristics of blood cells and the resistance change caused by blood cells suspended in electrolyte solution passing through the counting hole. This method is called resistance method or Coulter principle. 1962, the first domestic blood cell counter was successfully developed in Shanghai. In 1960s, blood cell analyzer could not only count blood cells, but also determine HGB hemoglobin at the same time. In 1970s, platelet counter came out. White blood cell classification (3 classification and 5 classification) was developed in 1980s. In 1990s, a blood cell analyzer was developed, which can count reticulocytes. At the same time, the 5-classification and immature cell detection are more mature and developed into a blood cell analysis pipeline.