Pyrazolamide is a succinate dehydrogenase inhibitor (SDHI) developed by Syngenta, and it is also a pyrazolamide fungicide, which contains four optical isomers. Its activity spectrum is wide and lasts for a long time, and it has protective and therapeutic effects, among which the protective effect is the main one, and the field test also shows certain therapeutic activity. It works by inhibiting succinate dehydrogenase (respiratory enzyme of complex ⅱ in mitochondrial membrane of pathogenic bacteria).
Pyrazolamide is mainly used in fruit trees, vegetables and cereal crops. It can effectively control wheat leaf spot, wheat stalk rust, wheat stripe rust, barley net leaf spot, wheat sheath blight and wheat sheath blight. The dosage of effective components is 75-65438 parts. It can also be used to control scab and powdery mildew on pears, powdery mildew, leaf spot and rust on vegetables, Sclerotinia sclerotiorum and stem spot disease on rape and fungal disease on bananas. The main formulations are emulsifiable concentrate and suspending agent.
Like methoxyacrylate fungicide, pyrazolone amide is also a respiratory inhibitor, but it is very effective against triazole and methoxyacrylate resistant bacterial strains, especially against fungi of the genus Alternaria. The control effect of this product on wheat rust and barley rust rot is better than that of epoxiconazole, and it still shows obvious effect after 7 weeks of field application, and its protection period is about 2 weeks longer than that of triazole fungicides.
At the beginning of 20 10, pyrazolamide was first registered in Britain, then registered in Ireland and New Zealand, and listed in the three countries in the same year. 2065438+On April 1 day, 2003, pyrazolamide was officially registered in the European Union, valid until March 3 1 day, 2023. Bontima, a compound product of 62.5 g/L pyrazole sulfonamide and 187.5 g/L from cyprodinil, which is listed in the UK, is used for disease control of winter barley and spring barley. The effective components of pyrazole-napthalonil compound are: epoxiconazole (the trade name of the compound product is Segregas, the same below), azoxystrobin (Reflectixtra, Symetra) and difenoconazole (Reflectitop, Embrelia).
Pyrazolamide belongs to four new products developed by Syngenta in 2009-20 12. These four new products are: grain bactericide 520 (ipratropium), seed treatment bactericide 524 (sukesong), herbicide 449 (dicyclopyramid) for corn and sugarcane fields, and pesticide Cysulfuron from DuPont. Fluconazole is also a succinate dehydrogenase inhibitor.
On March 24th, 20 14, Swiss Syngenta Crop Protection Co., Ltd. obtained the temporary registration of 95% fluconazole and 44% fluconazole suspension seed coating agent in China, valid until March 24th, 20 15. 44% fluconazole suspension seed coating agent was registered for corn seed coating agent to control head smut, and the dosage was 15 ~ 45g/ 100kg seed.
Triflumizole (,English trade name) is another succinate dehydrogenase inhibitor developed by Syngenta, which has an outstanding control effect on soybean rust in Asia with a long duration. Syngenta signed a global mutual authorization agreement with the bactericide oxathiapiprolin, which was awarded the Best Innovative Chemistry Award by DuPont in the 5th Agroawards. This is another technology licensing agreement between the two companies after the agreement between picoxystrobin and chlorantraniliprole eight years ago. At present, benzotriazole has not been registered in China.
Previously, Bayer and BASF also introduced succinate dehydrogenase inhibitors in China. For example, Bayer's fluopyram (annual peak sales of 200 million euros), BASF's fluxapyroxad (annual peak sales of 400 million euros) and boscalid (peak sales of more than 300 million euros) and so on. Thifluzamide of Nissan Chemical Co., Ltd. has blossomed everywhere in China because of the expiration of its patent.
In recent years, succinate dehydrogenase inhibitors have developed rapidly, showing a beautiful trend of unilateral increase. 20 1 1 year, the global sales of this kind of bactericide is 58 1 billion dollars, among which boscalid ranks first.
The world pesticide giants such as Syngenta, Bayer and BASF have all participated in the research and development of succinate dehydrogenase inhibitors, which will surely become another important product type after methoxyacrylate and triazole fungicides, and become an important engine to promote the growth of the fungicide market with its excellent performance.