Which is safer, hyaluronic acid or polyacrylamide? Hyaluronic acid, whose scientific name is hyaluronic acid, is a highly viscous substance first isolated from the vitreous body of bovine eyes. It is a naturally occurring linear polysaccharide compound. Hyaluronic acid molecules contain multiple hydroxyl groups and are very hydrophilic. They can bind to a large number of water molecules and have a strong effect in retaining moisture. They can maintain a suitable moist environment between cells and are natural moisturizing factors.
Hyaluronic acid is an important substance for human skin tissue to retain moisture. Hyaluronic acid in the skin helps the skin tolerate stress and protects subcutaneous tissue from damage. Hyaluronic acid also has a lubricating effect, allowing the skin to change shape and volume in a timely manner as bones and joints move.
However, the distribution of endogenous hyaluronic acid in the skin and body is constantly changing. As we age, hyaluronic acid decreases, and the corresponding ability of hyaluronic acid to bind water molecules decreases, which will lead to loss of skin volume, wrinkles and dry skin. Therefore, hyaluronic acid is used in plastic surgery.
Hyaluronic acid products used in medical cosmetology passed the certification of the US Food and Drug Administration (FDA) in December 2003, and passed the certification of the China Food and Drug Administration (SFDA) in December 2008. Certification. The main application areas of hyaluronic acid injection for beauty include wrinkle removal, facial contour shaping, facial depression filling, lip augmentation, etc.
Inadvertently, I found a notice on the official website of the State Food and Drug Administration. On March 28, 2018, the State Food and Drug Administration issued the "Consumption Warning on Polyacrylamide Hydrogel (Injection)". I was shocked at that time!
Why? Because polyacrylamide can cause cancer!
People who major in biology, pharmacy or medicine all know that when doing molecular biology experiments, polyacrylamide gel electrophoresis (SDS-PAGE) is used when running proteins. People usually wear masks for fear of being poisoned. One of the highly toxic substances is polyacrylamide. But I don’t know why it is used in the plastic surgery industry.
Let’s talk specifically about the toxicity of polyacrylamide. Polyacrylamide monomer is highly toxic, but the toxicity is reduced due to cross-linking after forming a gel. However, special attention should be paid to the fact that polyacrylamide hydrogel may decompose and become highly toxic after being injected into the human body. Because it can decompose into highly toxic monomer molecules in the human body, poisoning the nervous system, damaging the kidneys, and causing damage to the life circulation system, the World Health Organization has listed this substance as one of the suspected carcinogens.
It’s scary to think about using polyacrylamide hydrogel instead of hyaluronic acid for plastic surgery!
The former State Food and Drug Administration revoked the "Medical Device Registration Certificate" for polyacrylamide hydrogel (injection) and other related products on April 30, 2006, and completely stopped the use of this product. Production, operation and use.
However, after checking the relevant information, I feel that using polyacrylamide hydrogel instead of hyaluronic acid for plastic surgery may be a historical issue!