"Epilepsy buster" capsule, which has a remarkable curative effect on children's epilepsy, won the silver prize in the 5th China New Technology and New Products Expo and the gold prize in the China New Technology Achievements Patent Products Expo, and was allowed to export abroad.
"Epilepsy buster" is a traditional Chinese medicine preparation invented and developed by Tian Hua, director and researcher of Epilepsy Research Office of Henan Institute of Traditional Chinese Medicine, on the basis of ancestral ancient prescriptions. According to the clinical observation of 2 16 epileptic patients under 2 years old, the total effective rate of "epilepsy buster" is 98%, and the remarkable effective rate is 9 1%.
Compared with the literature of the same period, the curative effect of "Epilepsy buster" on epilepsy is obviously higher than that of other antiepileptic drugs. Used for the treatment of children, superior to other age groups, without toxic side effects. The study also confirmed that "epilepsy buster" can obviously improve the EEG abnormalities of epileptic children, with an improvement rate of 66%.
Hong kong ta kung pao
Observation on the therapeutic effect of Xianxianxing capsule on epilepsy in children! Epilepsy is a common and frequently-occurring disease, which mostly begins in early childhood, so the treatment of epilepsy in children has been concerned by all parties. A group of children with epilepsy under 12 years old in our hospital were treated with Diankexing capsule.
I. Clinical data
1, general information:
265,438+06 outpatients were diagnosed as epilepsy by clinical and EEG examination (some cases were examined by CF and MRI), and they were under 65,438+02 years old and took Diankexing capsule for more than 6 months. Male 136, female 80, the youngest onset age is 3 months, and the average onset age is 4.9 years. The shortest course of disease is 2 months, the longest is 12 years, and the average course of disease is 3.6 years. The shortest course of treatment was 6 months and the longest was 48 months, with an average course of treatment of 13.4 months. Etiology includes infection in 29 cases, birth injury or brain injury in 38 cases, febrile convulsion in 52 cases, genetic tendency 15 cases and disease (inducement).
2 16 cases were treated with epilepsy star capsule alone, but other Chinese and western antiepileptic drugs were not suitable. After taking epilepsy star capsule, the original antiepileptic drug was gradually stopped. During the treatment, EEG, ECG, blood routine, urine routine, platelet and liver function tests were carried out regularly.
2. Use drugs:
Epilepsy Star Capsule is a new and highly effective antiepileptic preparation developed by our hospital.
Prescription: Arisaema cum bile, concretio silicea bambusae, artificial bezoar, pearl, Uncaria, etc.
Usage: Take orally, 1/8-L capsules each time according to the age of children. If the attack pattern is obvious, the dose can be increased appropriately 3 hours before the attack, and the daily dose can remain unchanged.
Second, the result
In order to accurately evaluate the curative effect and facilitate the comparative analysis of the curative effect, this paper still formulated a four-level judgment standard according to the standards put forward by 1979 Qingdao National Epilepsy Seminar and related materials.
Complete control: epilepsy has not recurred, and the time has exceeded the longest interval before taking medicine by more than 2 times.
Basic control: the attack frequency is reduced by more than 75%, and the symptoms are alleviated. (significant effect)
Effective: the attack frequency is reduced by 50%-75%, and the attack degree is reduced.
Ineffective: the above treatment effect can not be achieved, or there is no significant difference before treatment.
According to the above criteria, there were 265,438+06 cases in this group, 65,438+06 cases were completely controlled, accounting for 53.70%, 40 cases were basically controlled, accounting for 65,438+08.52%, 54 cases were effective, accounting for 25.00%, 6 cases were ineffective, accounting for 2.78%, and the effective rate was 72.22.
Among 2 16 cases, 157 cases had abnormal EEG before treatment, and the positive rate was 72.69%. After taking 157 cases, 65 cases completed EEG reexamination on time, and the detection rate was 4 1.40%, of which 2 cases had returned to normal, 13 cases were obviously improved, 28 cases were improved, 22 cases had no obvious change, and the improvement rate was 66. 15%.
There was no obvious abnormality in routine electrocardiogram, routine hematuria, platelet and liver function examination during medication.
Although there were 47 cases of drowsiness, dizziness, fatigue, impatience, hyperactivity and other uncomfortable reactions, these reactions were not only mild, but most of them appeared in the early stage of taking the medicine. Except for a few cases that need to adjust the dose once a day, it generally does not need special treatment and disappears in a short time.
Three. discuss
Traditional Chinese medicine's discussion on the etiology of epilepsy is nothing more than wind, phlegm, fire and shock. Because wind is active, convulsions and phlegm are dizzy, so wind and phlegm are the basis of disease. This prescription mainly focuses on promoting qi circulation, resolving phlegm and clearing heat, and calming wind, and gradually regains consciousness by calming wind, smoothing qi, resolving phlegm and dredging heart. The prescription takes Arisaema cum bile, concretio silicea bambusae, clearing away heat and resolving phlegm, calming the heart and calming the convulsion as the main drugs, and bezoar, pearl, antelope horn and Uncaria rhynchophylla as the auxiliary drugs. Used to clear liver and gallbladder heat to avoid heat and wind, gastrodia elata, scorpion, cicada slough, silkworm and so on. It is used to stop wind and relieve spasm, Acorus gramineus, etc. are used to guide stagnation and resolve phlegm, and Salvia miltiorrhiza and amber are used to promote blood circulation and remove blood stasis. At the same time, in view of the fact that the products for eliminating pathogenic factors and guiding stagnation are easy to refine body fluid and damage qi, and epilepsy has a long course and recurrent attacks, adding nourishing yin liquid such as Radix Paeoniae Alba and Radix Polygalae will make yin grow and yang grow, and metaplasia be active. This recipe is closely related to the pathogenesis of heart and liver and the pathogenic process of phlegm, qi and fire, and integrates the functions of clearing away heat and soothing the liver, calming the liver and calming the wind, guiding phlegm and removing blood stasis, nourishing yin and benefiting qi, inducing resuscitation and calming the heart in one furnace. It not only has remarkable antiepileptic and anticonvulsant effects, but also is suitable for various types of epilepsy syndrome. Compared with the literature of the same period, the curative effect of Epilepsy Star Capsule in controlling epileptic seizures is obviously higher than that of general antiepileptic drugs, and it is superior to other age groups when used in the treatment of children.
Although there are still different views on the relationship between the clinical efficacy of antiepileptic drugs and EEG effect, most scholars agree that EEG is not only of great significance to the diagnosis of epilepsy and the discovery of lesions, but also of great reference value to the evaluation of curative effect and the use and reduction of antiepileptic drugs. This observation supports the above viewpoint, and EEG can reflect the degree of clinical control. Although its improvement obviously lags behind the clinical improvement, epileptic discharge generally decreases or even disappears with the continuation of treatment time. The EEG data of 65 cases in this group were complete, the average course of treatment was 65438 04.8 months, and the improvement rate of EEG was 66.65438 05%, which indicated that the EEG effect of Diankexing capsule was encouraging.