Other functions of glabridin.

In the comprehensive experiment conducted by Yokota et al., the anti-melanin and anti-inflammatory effects of glabridin were tested, and the relationship between the structure of glabridin and its effects was also studied. In order to test the whitening activity of glabridin, the brown back of guinea pigs was irradiated with ultraviolet rays and then coated with 0.5% glabridin. It is found that glabridin can significantly reduce the pigmentation caused by ultraviolet radiation. At the same time, the skin in the smeared area was studied histologically. This part of skin tissue was smeared with 0. 1% dopa, and the number of dopa-positive melanocytes per square millimeter was calculated under the optical microscope. So as to evaluate the ability of glabridin to inhibit melanin formation. Through surface tissue study, it can be found that the number of dopa-positive melanocytes in the drug group is reduced, and the use of glabridin can also increase the luster of the skin. The researchers concluded that glabridin in Glycyrrhiza uralensis Fisch can not only inhibit the formation of melanin, but also resist inflammation. It is also observed that these effects of glabridin are related to its chemical structure.

The main mechanism of glabridin inhibiting melanin is as follows: glabridin has excellent anti-inflammatory, anti-oxidation and anti-melanin formation, so it is used as a component of various cosmetics and health care products (such as creams, lotions, bath lotions, etc.). ). It can be made into whitening cream, and there are such patented products on the market now.

Dosage: In cosmetics, the recommended dosage is 0.00 1-3% glabridin, preferably 0.001-kloc-0/%. And glycerol 1: 10, and added at low temperature. Glabridin for external use can inhibit the formation of melanin. It has excellent tyrosinase inhibitory activity and can prevent skin from tanning, fine lines and sunburn. The recommended dosage is 0.0007-0.05%. If it is to inhibit androgen and treat acne, the dosage of glabridin is 0.0 1-0.5%.

Scientists in China also studied the preparation of glabridin liposome and its application in beauty cosmetics. The results showed that glabridin liposomes could be successfully prepared by liposome method and preparation technology. The phospholipid bilayer membrane of glabridin liposome is similar to a biofilm, which is easy to fuse with it, promotes the penetration of functional components into the biofilm, makes the transport efficiency of functional components across the skin barrier and biofilm higher, and plays a positive role in improving and improving its skin whitening and freckle removing effect and other auxiliary effects. 40% of glabridin comes from glabridin, which is the most widely sold in the market at present. It is mainly composed of licorice flavonoids and is brown or white powder. Sabinsa Company of the United States is one of the earliest companies to produce glabridin in the world. Because 40% of Glycyrrhiza glabra produced in glabridin is extracted from Glycyrrhiza uralensis Fisch, it is also called Glycyrrhiza flavonoids, which is the active ingredient with the best whitening effect. In the cosmetics industry, it is known as "whitening gold". Adding 0.05-0.2% of 40% glabridin, dissolving with PEG-400 at the ratio of 1: 8, and adding at low temperature at the last stage of the formula.

References:

1., Pei Chen, Ma Ling, Zhan Xiaoping, Wang. Determination of liquiritin in Glycyrrhiza uralensis Fisch by HPLC [J] Ningxia Medicine, 2006, (08)

2. Cui and Wu Hao. Determination of liquiritin, liquiritin and isoliquiritigenin in Compound Glycyrrhiza Mixture by dual-wavelength HPLC [J] Chinese Patent Medicine, 2002, (03).

3. Ding Kexiu. Preparation of glabridin Liposomes and Biomedical Principles of Their Application in Cosmetics, Proceedings of the 1 1 Southeast Asia Medical Beauty Conference.

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