Most of the cells in the human body are terminally differentiated cells, which have no ability to divide again and will eventually die of aging; But at the same time, some undifferentiated primitive cells, that is, stem cells, remain in the body. Stem cells produce new stem cells or differentiate into new functional cells under certain conditions, thus maintaining the dynamic balance between the growth and decline of tissues and organs. When the process of decline is greater than the ability of re-growth, it shows aging.
The persistence of stem cells in the body makes them vulnerable to the accumulation of toxic metabolites related to aging. With the increase of age, stem cells in many tissues undergo profound changes, and eventually cell death, aging or loss of regeneration function occur, which is manifested in the slow response of the aging body to tissue injury, unbalanced proliferation activity, and decreased cell renewal and tissue regeneration functions. If the number of young stem cells in the body increases, the process of tissue aging will be delayed or even blocked.
02 endogenous stem cells anti-aging
Studies have confirmed that injecting young people's blood, calorie restriction or life-prolonging drugs into the aging body can also enhance the stem cell function of the aging body to a certain extent, so that the aging body presents a younger cell state. On the one hand, this method needs enough high-quality endogenous stem cells, but it is difficult for aging organisms to meet the standards; Secondly, just as the repair of damaged DNA needs to identify the main regulatory genes and autophagy of cells must be selectively controllable, there is still a long way to go to achieve anti-aging effect through the intervention of endogenous stem cells due to the complexity of mechanism and implementation means.
Another direction of stem cell anti-aging-using exogenous stem cells to correct the aging problem of the body has been widely studied and applied.
Anti-aging effect of exogenous stem cells
At present, a large number of anti-aging stem cells have been studied, and it is found that stem cells existing in the whole life process of the body have the functions of antioxidation, anti-wrinkle and promoting wound healing. Experiments show that dermal pluripotent stem cells (DMSCs) can prevent skin aging by increasing the level of type I collagen and skin thickness, and can increase the number of skin precursor cells and the ability of epidermal regeneration together with dermal stem cells (DSCS).
Therefore, it is easier to achieve anti-aging by using exogenous stem cells for the following reasons: ① The mechanism of action is simple and controllable: at present, there are two kinds of transplantation methods: intravenous infusion and local transplantation (filling); ② The number of transplants can be controlled; ③ The effect is obvious.
Anti-aging effect of exogenous stem cells
The above comprehensively tells the anti-aging mechanism of stem cells. The function of stem cells on human body is to improve the overall body function, improve sub-health and delay aging. At the same time, the physiological differences between men and women can be intervened according to the local physical condition.
1 improve body function as a whole
Exogenous stem cells enter the body through veins and are transported to many parts of the body with blood, which improves the metabolic capacity of the body as a whole and improves the sub-health state. On the other hand, aging leads to the decline of immune cells, activity and disease resistance, so diseases such as tumors are prone to occur. Exogenous stem cells can secrete a variety of effective components after implantation and regulate the immune system of the body.
2 Women's anti-aging
Beauty beauty, enhance skin elasticity and prevent wrinkles; Improve women's menstrual problems; Postpone female menopause, improve menopausal syndrome and delay aging; Promote breast development and restore sagging breasts.
3 male anti-aging
Improve physical strength and energy, improve the overall function of the human body; Speed up thinking and reaction ability; Improve sexual function; Improve prostate problems; Eliminate obesity and beer belly.
4 disease treatment
Using the ability of stem cell proliferation and multi-directional differentiation to regenerate new tissues and organs, rather than damaged and decayed tissues, can fundamentally achieve the purpose of treating diseases and delay the aging speed of the body. At present, the fields involved in stem cell therapy include: immune system diseases, nervous system diseases, inflammatory diseases and tissue regeneration.