1, functional development
Solutions to the coating problem of volatile substances in traditional Chinese medicine
The volatile substances in traditional Chinese medicine are mainly borneol, volatile oil and other substances. Bokolin Company specially conducts comparative experiments on coating formulations of these characteristic substances. Verified by a large number of data, the proportion of formula materials is reasonably selected, the pores of the coating film are reduced, and a dense network structure is formed through cross-linking, which plays the roles of sealing the coating film, covering up the taste, preventing oil return and preventing the loss of volatile effective components of drugs.
& ampOslash's method to solve the problem of moisture absorption and softening
Moisture-proof is the function needed for coating of most traditional Chinese medicine preparations. Many traditional Chinese medicine preparations have complex ingredients and strong hygroscopicity, which will change color and soften after hygroscopicity. Special moisture-proof formula, effective protection of drugs. Moisture-proof and disintegration are a contradictory unity, so it is necessary to ensure that the preparation is completely disintegrated in an effective time while solving moisture-proof. The professional R&D team of Bokolin Company looks for coatings with better moisture-proof performance. Through different combinations and proportions of coatings, the moisture-proof and solubility characteristics of coatings and their solubility in water at different temperatures and humidity are studied. At present, a series of moisture-proof formulas have been developed, which can be selected from the aspects of operation difficulty, moisture-proof index and appearance effect according to customer requirements.
Protection of multivitamin drugs in & ampOslash
Oxygen will oxidize the pharmaceutical ingredients, especially vitamins. Drugs often appear discoloration, content reduction and other problems, affecting medication. In order to obtain the film coating premix that meets the requirements, Bokolin Company comprehensively screened and designed a reasonable formula through the combination of composite film materials and additives, and through a series of strict product tests such as permeability, optimized the performance of the product, and finally formed a reasonable composite coating agent, which improved the barrier performance of the film to water vapor and oxygen, was completely isolated from the drug components, effectively solved the drug oxidation phenomenon, and no longer appeared discoloration, mottling, exudation and other phenomena, thus prolonging the shelf life of the drug.
2, the convenience of operation is improved
Film coating is an important link in drug production and processing. Improving the convenience of operation, improving efficiency and reducing cost consumption are the development directions of coating agents. Compared with sugar coating, film coating reduces labor intensity and greatly improves production efficiency. However, in actual production, many manufacturers still need to speed up the coating. The main reasons are: effective use of working hours to improve production efficiency; Shortening the operation time can reduce the wear and component loss of drugs and improve the actual weight gain of drugs. Therefore, the research of rapid coating technology has important significance and market application value.
The improvement of coating speed is related to two factors. The first is the formulation performance of the coating agent, such as solution viscosity and concentration. The second is the processability of the coating agent, such as the adhesiveness during operation and the fluidity of the coated tablets.
With the increase of the concentration of & ampOslash solution, the production time is shortened.
The main raw material of film coating agent is polymer compound, and the viscosity of different types of solutions will be obviously different. The coating agent commonly used in the market has high viscosity, and the solution concentration is usually set at 8- 12%. Bokolin Company introduced a coating formula with low viscosity and high solid content. The viscosity of the solution is reduced, the concentration of the solution can be increased to 18-20%, the solvent consumption is greatly reduced, the operation efficiency is improved, and it is widely used.
& ampOslash rapid coating technology, better operational performance.
According to the coating principle and application equipment, the rapid coating formula is designed reasonably, which not only improves the spraying speed, but also avoids the phenomenon that the tablet core is too wet to stick to the tablet. It has good operability, saving nearly 65,438+0/3 working hours compared with ordinary coating agent. The situation that the weight of the tablet core can not meet the weight requirement of the tablet due to water loss and powder removal of the medicine is reduced.
3, advanced technology to improve quality
The conventional production method of coating agent is usually ball milling or grinding to treat insoluble colorant. Ball milling method takes a long time and has poor dispersion effect. The crushing method causes uneven color of products, precipitation in operation, gun blockage and other phenomena, and also causes molecular chain breakage or denaturation of polymer materials, which affects the film-forming performance of products.
Bokolin recently refined and dispersed insoluble colorants into very fine particles by high shear method. Then, the surfactant solution is atomized under high pressure to form fine droplets, which are evenly distributed on the surface of the colorant to form a uniform coating. This method can quickly and fully wet the colorant particles, reduce the surface energy of the lake particles, avoid particle agglomeration, make the colorant evenly dispersed and stable, improve the coloring strength of the product and obviously improve the hiding power. In the shearing process, the coated colorant and the film-forming agent are evenly mixed, and the color of the product is consistent, and at the same time, the plasticization of the film-forming agent is realized and the flexibility of the product is improved.
In this production process, the colorant forms fine powder, which improves the brightness of color, and the powder is fine and stable to use. In the mixed plasticization of film forming agent, short-time low-speed shearing can be used to obtain evenly mixed materials, which avoids the damage of high-speed long-time shearing to the molecular structure of polymer materials.
The production process has been authorized by the invention patent, and all coating agents of Bokolin company are produced by this method, which improves the product quality and the coating effect of drugs.
According to the characteristics of multi-component combination of film coating premix, Bokolin Company adjusted the ingredients and material ratio in the formula, designed the formula of coating premix flexibly, developed a coating agent that can meet the needs of traditional Chinese medicine, improved the quality of traditional Chinese medicine preparations, and made the coating agent products play an important role in the variety development of modern traditional Chinese medicine preparations.