Growth hormone electronic pen patent

Growth hormone is a kind of protein secreted by the anterior pituitary gland, which consists of 19 1 amino acid. Has the functions of promoting growth, regulating substance metabolism and degrading fat. It can promote bone growth and play a very important role in human growth and development. If we lack growth hormone, it will lead to slow growth and development of children, leading to short stature. At present, recombinant human growth hormone has the same function as human growth hormone, and can also promote the growth of bones, internal organs and the whole body, and is often used to treat dwarfism and dwarfism in children.

The earliest growth hormone was extracted from the pituitary gland of a person who just died in 1958. It was banned in 1985 because of its limited source, low yield, low purity, many antibodies and easy contamination by donor viruses.

1985, recombinant human growth hormone composed of 192 amino acids was produced by inclusion body technology of Escherichia coli. Although it was mass-produced, it was not completely consistent with human growth hormone, and the incidence of antibody was still high, so it was delisted in 2004.

1987, the recombinant human growth hormone powder consisting of 19 1 amino acid produced by the gene expression technology of Escherichia coli was put on the market. Although its primary structure is consistent with natural growth hormone, its secondary and tertiary levels are different, so the antibody production rate is still high.

1995 combines the gene expression technology of Escherichia coli with the liquid phase stabilization technology of protein to produce a growth hormone aqua, which ensures the natural structure of growth hormone, and has higher activity, faster onset, better curative effect and safer long-term use.

In 20 14, a long-acting PEG growth hormone aqueous solution independently developed by China was born. It connects inert PEG with natural growth hormone by natural peptide bond, which greatly reduces the speed of its filtration by kidney, reduces the degradation of protease and improves the stability of growth hormone in human body. At the same time, inert PEG and natural peptide bond are harmless to human body, safe and reliable. With PEG "blessing" long-acting growth hormone aqueous solution, the elimination speed of drugs in the body after injection is greatly slowed down, thus achieving the effect of once-a-week injection. Long-acting growth hormone only needs to be injected once a week, so that children can bid farewell to the pain of daily injection, from 365 injections a year to only 52 injections a year, which better eliminates the fear of daily injection. At the same time, the biological effect of pulse is better simulated, so the curative effect is better than the short-term effect. Nowadays, growth hormone has fully entered the era of weekly treatment.