It is generally recommended to have routine gynecological examination before hpv vaccination, such as gynecological physical examination, vaginal secretion examination, human papillomavirus examination, TCT examination and so on. For women who have never had sex, it is generally impossible to carry out the above examination, just make an appointment for vaccination according to the routine. For women who have sex, it is necessary to check vaginal secretions and conduct cervical cancer screening to determine whether there is infection. If there is an infection, it is generally recommended to vaccinate again after a period of treatment and the body's resistance is enhanced. This is not a hard and fast rule. If the vaccinator has a strong desire to vaccinate, he can vaccinate before the infection has healed.