If you want to detect whether your P53 gene has deletion mutation, do you want to do whole gene sequencing? If we only check polymorphism, can we check all of them? Is it just a genetic mutation?

If you are in the laboratory, you only need to design a pair of primers, take some oral epithelial cells (scrape them with cotton swabs), do a pcr, make a gel and see for yourself.

Depending on whether it mutates,

The whole gene needs to be amplified, sent to a sequencing company for sequencing, and then exploded.

If you don't know, of course, it is best to consult a specialized institution, and a company with medical institution qualification is better.

(p53 is not necessarily a tumor, p3 is not necessarily a tumor. )

The polymorphism of p53 is normal without mutation or deletion, which means that p53 is normal. That's right.

Because polymorphism can be studied, it is proved that p53 is not deleted. Polymorphism refers to the situation of some mutation sites in this gene. Since the situation is normal, p53 is also normal.

As long as we check whether p53 is normal, we need to sequence the gene, but we don't need to sequence the whole gene.