Cefotoro compound patent expires.

A poem reminds you of the classification of five generations of cephalosporins:

Aladdin-oxazoline-ampicillin

Difluoropropene

Trioxime-statine-petriazine

Four generations of Pim rode horses.

Five generations of Lorraine Tollop

The first generation: Aladdin, Lin Anpising

Cefradine, cefazolin, cefalexin, cefadroxil

The second generation: desflumet, gram propylene

Cefuroxime, Cefmondo, Ceftidine, Cefurol, Cefpropene

The third generation: trimetazidine and pethidine.

Cefotaxime, Cefotaxime, Cefotaxime, Ceftazidime, Ceftriaxone.

The fourth generation: the fourth generation of pyridoxime, riding a horse.

Cefpirome; cefpirome

Fifth Generation: Lorraine and Turop in the Five Dynasties.

Cefololin, Cefotoro, Cefopiride

Cephalosporins are a series of semi-synthetic antibiotics obtained by modifying the side chain of cephalosporin C isolated from Cephalosporium coronatum culture medium.

Its advantages are wide antibacterial spectrum and high efficiency for anaerobic bacteria; The allergic reaction caused by penicillin is lower than that caused by penicillin. Stable to acids and β -lactamases produced by various bacteria; The mechanism of action, like penicillin, is to achieve the purpose of sterilization by inhibiting the formation of bacterial cell walls.

Belonging to a bactericide in the breeding period. Because of its low adverse reactions and toxic side effects, it is a kind of antibiotics that is developing rapidly at present.

Cephalosporins and penicillins belong to β -lactam antibiotics. The difference is that the mother nucleus of cephalosporin is 7- aminocephalosporanic acid (7-ACA), while the mother nucleus of penicillin is 6- aminopenicillanic acid. This structural difference makes cephalosporins resistant to penicillinase.

References:

Cephalosporin Baidu Encyclopedia Cephalosporin Baidu Encyclopedia