The basic introduction is from Baidu Encyclopedia:
The content of water-soluble florfenicol is divided into 10%, 20%, 30%, 50%, 70% and 90%. It is developed to solve the water solubility of florfenicol, using special co-solvent and advanced technology. It solves the problems of drinking water for livestock and poultry and medicated bathing of aquatic animals. It has the same effect as the raw material drug, but has higher bioavailability. It is an ideal drug for treating bacterial diseases of livestock, poultry and aquatic animals, with good effect and wide indications.
Edit this paragraph 70% water-soluble florfenicol
Basic characteristics:
The main ingredient is florfenicol.
70% water-soluble florfenicol
Properties: This product is a white or off-white powder that dissolves in water.
Pharmacological effects: This product is a broad-spectrum antibacterial drug that strongly interferes with bacterial protein synthesis. It is rapidly absorbed and widely distributed in the body.
It has a long half-life, no aplastic side effects, is not prone to drug resistance, has no residue, and has no cross-resistance. It is an alternative to chloramphenicol and chloramphenicol. Thiamphenicol is a new generation of chloramphenicol antibiotics.
Indications are mainly used for bacterial diseases and mycoplasma infections in pigs, chickens and fish caused by sensitive bacteria, diseases caused by large intestine of livestock and poultry
Pig contagious diseases It has unique curative effect on pleuropneumonia and asthma.
Usage and dosage Mixed feeding: 1g of this product is mixed with 10-20kg for livestock and poultry, and can be fed ad libitum. Double the amount for the first time and feed it continuously for 1 week.
Drinking water: For livestock and poultry, add 1g of this product to 10-20kg of water and drink freely. Use for 1 week. Double it for the first time, halve it for prevention.
The drug withdrawal period is 30 days.
Precautions 1. Use with caution in pregnant animals. 2. This product does not cause aplastic anemia, but cattle may experience short-term anorexia, decreased drinking water, diarrhea and other adverse reactions after use. 3. Do not use it in combination with β-lactams, aminoglycosides, and rifampicin drugs.
Florfenicol series
Packaging specifications: 10kg, 25kg
Experimental report:
Type I florfenicol amber Comparison table between sodium chloride and type II microencapsulated florfenicol sodium succinate:
Product name pH content/% Process characteristics Product advantages and disadvantages Application instructions
Type I Florfenicol sodium succinate
(Jinan Huimeng’s first domestic patent number 200810015571) 7~8 ≥95% The chemically synthesized solution is unstable, easy to deliquesce and agglomerate, and is prohibited to be compounded with doxycycline hydrochloride< /p>
Type II florfenicol sodium succinate
(microcapsule coating) 4~6 ≥98% chemical synthesis, microcapsule coating solution is stable, slowly released, not affected by pH (PH value), water temperature, non-caking doxycycline hydrochloride, tylosin, neomycin sulfate, lactic acid TMP can be compounded
Efficacy and Indications: Chicken colibacillosis and duck serosa inflammation, intestinal respiratory diseases caused by mycoplasma in cattle, pigs and sheep
Usage and dosage: Mix and drink, according to the effective amount. Poultry: 5g/100kg water.
Features: Not affected by water temperature, completely dissolved, rapidly absorbed, and high biological potency.
Jinan Huimeng Biotechnology Co., Ltd. launched strongly.
If you need the formula, please contact our company.
The performance comparison of various water-soluble florfenicols is as follows:
Synthesis method Product name Content % Solubility/100ml Dissolution rate remarks
Chemical synthesis method Fluorfenicol Sodium Nicosuccinate (first domestically produced by Jinan Huimeng
Patent No.: 200810015571) ≥95 100 000 Quick powder, injection (colorless and transparent)
Physical method
< p>(Domestic current situation) PEG6000 dispersion ≤10 37.01 Slow oral administrationPhysical method
(Domestic current situation) PVPK dispersion ≤30 14.39 Slow oral administration
Physical Method
(domestic current situation) Polysaccharide dispersion ≤10 39.12 Slow oral administration
Physical method
(domestic current situation) β-cyclodextrin inclusion ≤25 9320 Slow oral administration (with floc)
Physical method
(Domestic current situation) Hydroxypropyl beta-cyclodextrin inclusion ≥44 46300 Fast and expensive
Jinan Huimeng Biotechnology Co., Ltd. second generation cosolvent ≥70 200 Fast clear and transparent
Edit this paragraph 90% ice water soluble florfenicol
There are many florfenicol It has practical value, but there is still a problem that is difficult to solve, that is, it is difficult to dissolve in water, has low utilization rate, and cannot fully exert its medicinal effect. This problem has not been solved well. At present, the technology for florfenicol water solubility in my country is physical methods: co-solvent micronization, β-cyclodextrin inclusion, hydroxypropyl β-cyclodextrin inclusion, PVPK dispersion, PEG6000 dispersion, ultrafine, and grinding The dissolving effect of other methods is generally unsatisfactory, with slow dissolution speed and low dissolution, making it difficult to meet the needs of preparations and concentrated formulations. Our company adopts the most advanced international chiral synthesis technology to use D-threo-2-amino-1 -(p-methylsulfonyl)phenyl-1.3-propyl alcohol is used as raw material, and florfenicol is synthesized under the action of chiral organic zinc and YH-3 catalyst. It dissolves in water quickly and is metabolized by the body after entering the animal body. The biological activity is enhanced. In clinical trials, it is better than florfenicol in treating poultry colibacillosis, duck serositis, swine asthma, yellow and white diarrhea in piglets, etc., successfully solving this problem that has not been overcome by the academic community.
90% ice-water soluble florfenicol (chiral synthesis)
Features: 1. Not affected by water temperature, completely dissolved, rapidly absorbed, high biological potency, equivalent to ordinary water-soluble 1.5 times the potency of florfenicol.
2. The unique optically active molecular structure is not prone to drug resistance, regulates immune cytokines, and regulates inflammatory signaling pathways.
3. Inhibits bronchospasm, anti-allergic, and has obvious effects on the respiratory tract.
Note: It is prohibited to mix with alkaline drugs
Manufacturing company: Jinan Huimeng Biotechnology Co., Ltd.
Address: No. 2 Ma'anshan Road, Jinan City.
Edit this paragraph's instructions for water-soluble florfenicol
Main ingredients
Florfenicol
Characteristics
< p>This product is a white or off-white powder that dissolves in water.Pharmacological effects
This product is a broad-spectrum antibacterial drug that strongly interferes with bacterial protein synthesis. It is rapidly absorbed, widely distributed in the body, has a long half-life, has no aplastic side effects, is not prone to drug resistance, has no residue, and has no cross-resistance. It is a new generation of chloramphenicol antibiotics that replaces chloramphenicol and thiamphenicol.
Indications
It is mainly used for bacterial diseases and mycoplasma infections in pigs, chickens and fish caused by sensitive bacteria, for diseases caused by Escherichia coli in livestock and poultry, and for pig infectious diseases. It has unique curative effect on pleuropneumonia and asthma.
Usage and Dosage
Mixed feeding: 1g of this product is mixed with 10-20kg of livestock and poultry, and can be fed ad libitum. Double the amount for the first time and feed it continuously for 1 week.
Drinking water: For livestock and poultry, add 1g of this product to 10-20kg of water and drink freely. Use for 1 week. Double it for the first time, halve it for prevention.
(Provided by Jinan Shanpeng Economic and Trade Co., Ltd.)
Notes on editing this paragraph and others
Withdrawal period
30 days< /p>
Precautions
1. Use with caution in pregnant animals.
2. This product does not cause aplastic anemia, but short-term anorexia, reduced drinking water, diarrhea and other adverse reactions may occur in cattle after use. 3. Do not combine with β-lactams, aminoglycosides, rifampicin and other drugs.