Flonicamid went public in 2003, with sales of $35 million in 2009 and a compound annual growth rate of 28.50% from 2004 to 2009. The annual sales of 20 10 was USD 40 million, up by 14.29% year-on-year. Ishihara Industries has set the global sales target of flonicamid, with annual sales of at least 50 million US dollars. At present, this goal is not far away.
Flonicamid's market started in the United States, and then set foot in Europe, Asia and Latin America. Up to now, it has been registered and listed in more than 30 countries around the world, such as the United States, France, Britain, the Netherlands, South Korea, Brazil, Colombia, Japan, China, Italy, India and Australia. On September 26th, 2003, fipronil was first registered in the United States. On September 20 1 year 1 day, fipronil was included in the list of registered active ingredients in EU pesticide registration regulations (1 107/2009), and it will be valid until August 3 1 day, 2020. From July 2065438 to July 2003, the patent protection of fipronil in Europe, the United States and China expired almost at the same time. On September 25th, 20 13, the protection of its registered data in the United States expired; On August 3, 2020, the protection of its registered data in the European Union was terminated. Therefore, in 20 13 years, fipronil has become an expired product in China, the United States and Europe. However, as of 20 13, 12 and 12, no China enterprise had registered fipronil except for sub-packaging registration. ?
The mechanism of action of flonicamid is novel, and it has good neurotoxicity and fast antifeedant activity against sucking mouthparts pests such as aphids. Its blocking effect on aphid's oral needle makes it similar to pymetrozine, but different from pymetrozine, it can enhance the spontaneous contraction of migratory locust's foregut. It is neurotoxic, but it has no effect on acetylcholinesterase and nicotinic acetylcholine receptor, which are typical targets of neurotoxic agents. The International Action Committee on Insecticide Resistance classifies fipronil into 9C categories: selective homopteran antifeedant, which is the only member of this group of products. "Unique member" means no cross-resistance with other pesticides.
After fipronil is used to suck up plant juice, biting mouthparts quickly stop eating within 30 minutes, which is irreversible. No excrement appeared in 1 h, and the pests who were prevented from sucking juice eventually starved to death.
Flupyrazole has selectivity, systemic property, strong penetrability and long duration, and can be used for fruit trees, cereals, potatoes, rice, cotton, vegetables, beans, cucumbers, eggplants, melons, tea trees and ornamental plants to control sucking mouthparts pests such as aphids, whiteflies, brown planthoppers, thrips and leafhoppers, among which it has excellent control effect on aphids. Foliar spraying, the dosage is 50 ~ 100 g active ingredient /hm2.
The global market value of juice-eating pest control agents is about $2 billion, among which neonicotinoid insecticides dominate the market authoritatively. The market of pymetrozine is in full swing in recent years; Although Tao Yinong's fipronil only shows sharp corners, dragonflies have long stood on it. Fipronil is especially suitable for cotton and rice crops, and it is the first sulfonimide pesticide compound with a new chemical structure. Its unrestricted registration in the United States covers nearly 40 crops or crop groups at a time. It is said that fipronil shows better performance than imidacloprid, a first-class pesticide on the market, and has no cross-resistance with the leading products at present.
In 2003, flupyrazole entered this highly competitive market with its unique mechanism of action, high biological activity and excellent control effect on aphids, and its annual sales in 20 10 was 40 million US dollars. Although this is not a billion-dollar product that everyone is used to paying attention to, it has been gathering its own energy at a growth rate exceeding the market average for several years after it entered the market. There are too many similarities between fipronil and fipronil in terms of simple chemical structure and crop control spectrum. When Dow Yi Nong promoted its new pesticide fipronil with great fanfare and marked its sales peak of $6,543.8 billion, fipronil, which was listed as early as nine years ago, quietly entered the list of products with expired patents. Moreover, the patent of thiamethoxam expired in China and Europe in the same month, and in sharp contrast to the fiery heat of thiamethoxam, the scene of fipronil was silent. This "quietness" seems to be in contrast to flonicamid's performance. We might as well open our eyes to know and understand fipronil, and maybe it will become one of our candidate varieties. ? Flupyrazole is effective against all kinds of inhalator pests and has good penetration effect. It can penetrate from roots to stems and leaves, but its ability to penetrate from leaves to stems and leaves and roots is relatively weak. This drug works by blocking the sucking action of pests. The pest stopped sucking soon after taking the medicine and finally starved to death. According to the analysis of electronic insect sucking behavior (EM ⅲ), the pesticide can prevent the needle tissue of sucking pests such as aphids from being inserted into plant tissues. Spray 30-50g 10% water dispersible granules every 667m2 to control pests such as cucumbers and aphids. When it is used to control aphids in apple and other fruit trees, it is sprayed with 2500-5000 times of water with 10% water dispersible granule.