Pharmacology and Toxicology of Insulin Glargine Injection

Drug treatment classification: antidiabetic drugs. Long-acting insulin and its analogues. Air traffic control code: A 10AE. Insulin glargine is a human insulin analogue with low solubility in neutral pH solution. It is completely dissolved in the acidic pH(pH4) injection of this product. After injection into subcutaneous tissue, the micro-deposits formed by neutralization in acidic solution can continuously release a small amount of insulin glargine, thus producing predictable, long-lasting, stable and peak-free plasma concentration/time characteristics. Insulin receptor binding: The kinetics of insulin glargine binding to its receptor is very similar to that of human insulin. Therefore, it can be considered that it has the same effect as insulin mediated by insulin receptor. Insulin, including insulin glargine, mainly regulates glucose metabolism. Insulin and its analogues can reduce blood sugar by promoting the uptake of glucose by surrounding tissues such as skeletal muscle and fat and inhibiting the production of glucose in liver. Insulin inhibits lipolysis of adipocytes, inhibits proteolysis and promotes protein synthesis.