The prevalence of dementia with Lewy bodies ranks second among all dementias, second only to Alzheimer's disease, and it is a common neurodegenerative disease. Although there is no specific drug for treating dementia with Lewy bodies in clinic, the research and development team of Professor He Yingrui from the Department of Psychology of Sun Yat-sen University of Medical Sciences recently confirmed that ceftriaxone can be used to treat the disease, which also brings new dawn to patients and their families.
With the increase of age, the incidence rate is higher, and the average survival time is 5 ~ 7 years.
First, Japanese scholar Kosaka and his colleagues published a report on the anatomy of dementia patients. They found that there were many abnormal protein deposits in the cerebral cortex, diencephalon and brain stem, which led to progressive dementia and motor dysfunction. At that time, it was recognized as a rare variant dementia, and it was not until later that this disease was gradually taken seriously. According to statistics, the ratio of male to female with dementia with Lewy bodies is 1.5: 65438+.
Ceftriaxone can regulate genes to clear brain endotoxin.
Patients with dementia with Lewy bodies will not only suffer from cognitive deterioration, but also gradually develop mental symptoms such as stiff limbs, shaking hands, unstable walking, and even hallucinations. Because the symptoms are similar to Alzheimer's disease or Parkinson's disease, it is not easy to make a diagnosis at the initial stage. Professor He Yingrui explained, but the study found that ceftriaxone can regulate the gene to inhibit amyloid in the brain of patients with Lewy body dementia, prevent α -synuclein degeneration, and remove toxins from the brain of patients.
Ceftriaxone is helpful to promote neurogenesis and repair damaged brain tissue.
In addition, all the important substances related to neurodegenerative diseases can also be removed by ceftriaxone to reduce brain cell death and neuroinflammation; Professor He Yingrui confirmed that ceftriaxone can also help promote neurogenesis, grow new cells and repair damaged brain tissue, thus treating neurodegenerative diseases, which is expected to become a new weapon for the treatment of this disease in the future.
The research and development of patented new drugs is expected to become a new choice for patients.
With the aging of society, the number of dementia patients is increasing gradually. According to statistics, the total population of dementia in Taiwan Province Province has exceeded 260,000 in 20 16, and it is estimated that it may reach 670,000 in 20041year. That is to say, on average, there will be 3 people suffering from dementia per 100 people, and the annual nursing cost of each dementia patient is nearly 65438. It is a great burden to the family and society. At present, the new drug developed by Professor He Yingrui's R&D team has recently won patents from Taiwan Province, Japan and Canada, which is expected to provide better treatment for patients in the future.
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