Brief introduction to the contents of the manual of total synthesis route of new drug chemistry

This book mainly introduces the chemical synthesis methods of new drugs, covering all new molecular solid drugs * * * 1999 ~ 2007 approved by the US Food and Drug Administration (FDA). For each drug, the drug introduction, chemical structure information, chemical total synthesis route and so on are given. At present, most of these synthetic routes are used in pharmaceutical industry, which has high practicability and academic value. This book contains thousands of organic synthetic reactions, hundreds of synthetic methods of drug intermediates and several very valuable appendices. This book is suitable for pharmaceutical enterprises, chemical synthesis enterprises and other researchers who study drugs, as well as scientific research and teaching staff of pharmacy and organic synthesis in colleges and universities.

This book covers more than 1999 ~ 2007 new molecular entity drugs approved by the US Food and Drug Administration (FDA), *** 170. On the basis of comprehensive and systematic literature retrieval, the author carefully selected the latest, best and most practical chemical synthesis methods from a large number of scientific papers and patent specifications to introduce them. For each drug, this book gives its English name, Chinese name, chemical structure, chemical formula, relative molecular weight, chemical element analysis, drug category, CAS registration number of American Chemical Society, declared manufacturer, approval date, indications and basic information of drugs. Among them, the "basic information of drugs" part briefly introduces the mechanism of action of drugs.

The characteristics of this book

The book describes the synthesis process and flow of drugs in the form of synthesis roadmap. Most of these synthetic routes are chemical synthetic processes currently being used in pharmaceutical industry, which have high practicability and reliability.

This book gives the detailed chemical structures of starting materials, intermediates and reaction products involved in the reaction. The important chemical reagents, catalysts, solvents used, synthesis reaction conditions, detailed scientific and technological literature sources and patent numbers of each step of chemical synthesis reaction are given, covering the period 1920 ~ 2007.

The book * * * contains thousands of organic synthesis reactions and hundreds of synthetic methods of pharmaceutical intermediates. There are three very useful appendices at the end of this book.

This book is carefully designed and compiled by six chemists who have rich experience in American pharmaceutical field. The content is concise, easy to understand, practical and of high academic value.