There are several different subtypes of human papillomavirus (HPV) causing condyloma acuminatum, and the common ones are 6, 1 1, 16, 18 and 33. Some of them only cause benign hyperplasia of epithelial cells, which are HPV6 type, 1 1 type, and are called low-risk type (low-risk type); Some of them can cause malignant hyperplasia of epithelial cells, such as HPV 16, 18, 33, which are called high-risk type (high-risk type). The viruses that cause condyloma acuminatum are mostly HPV6 and 1 1, accounting for 70% ~ 90% of clinical cases. They cause verrucous hyperplasia around vulva and anus. This kind of cancer is less likely. However, a small part of condyloma acuminatum is caused by high-risk infection.
In recent years, with the development of human papillomavirus detection technology and the popularization of colposcopy, the detection rate of cervical condyloma acuminatum, which was previously considered relatively rare, has increased rapidly, and high-risk human papillomavirus infection of condyloma acuminatum has become more and more common. I shared a case with you in Weibo before. HPV3 1, 5 1, 58, 66, 82, 6/ 1 1 were detected from a small wart of the patient's vulva.
Different from HPV6, 1 1, the epithelial hyperplasia caused by HPV 16 and 18 infection is not verrucous, but patchy or patchy, especially in female cervix. When the cervix was smeared with 3% glacial acetic acid, the areas infected with HPV 16 and 18 became white spots. After the cervical epithelium is continuously infected by high-risk human papillomavirus, some people can develop cancer after several years and decades of development. After examining the cancer tissues of patients with cervical cancer, it can be found that about 90% of them are infected with human papillomavirus. Of course, the occurrence of cervical cancer is a complicated process, which is likely to be the result of the joint action of many factors. However, in the process of parasitism and replication of high-risk human papillomavirus in epithelial cells, its DNA may be integrated into the core material DNA of human epithelial cells, leading to gene mutation and malignant proliferation of cells, which is one of the factors of cervical cancer.
In addition to cervical cancer, high-risk human papillomavirus infection can also make some condyloma acuminatum, which initially showed benign hyperplasia, undergo other canceration years later. What is medically called bowenoid papulosis is carcinoma in situ occurring in vulva. Bowen's papulosis can be seen in the vulva of men or women. It is brown or brown-black flat papulosis, single or multiple, and generally has no conscious discomfort. But it is a precancerous lesion, and if it is not treated, it can gradually evolve into skin cancer.
There was once a little girl who was only 15 years old. She was infected with condyloma acuminatum because of puppy love. She is afraid that her parents will never come to the hospital again, which will affect her walking. At that time, there was a layer of warts on the girl's genitals, and ulcer bleeding had appeared in many places. In addition, the girl has been wearing sanitary napkins, and the closed environment has aggravated her condition and has developed into precancerous lesions. A * * * finally cured the disease in half a year. Let's not talk about sex education for adolescent children for the time being. Focus only on the disease. Don't feel that sexually transmitted diseases are difficult to talk about or don't want to go to the hospital because of various scruples. Although condyloma acuminatum is mostly benign, if it is not treated in time, it will not only lead to more and more lesions, but also increase the difficulty and cost of treatment. If there is high-risk human papillomavirus infection, it will also lead to the abrasion and rupture of warts.
It is reported that 5% ~ 10% of vulva, cervix and perianal condyloma can become cancerous, and after a long time, it develops into carcinoma in situ and invasive carcinoma. It was also found that 15% of penile cancer and 5% of female vulvar cancer occurred on the basis of the original condyloma acuminatum. Many experimental studies have also proved that there is a causal relationship between human papillomavirus, condyloma acuminatum and genital cancer. At present, condyloma acuminatum, syphilis and other sexually transmitted diseases are not serious diseases, but they can be cured clinically. After discovery, regular treatment must be carried out as soon as possible to reduce unnecessary pain.