Allergic probiotics mainly seek alternative antiallergic therapy other than drugs, and use active and non-pathogenic microorganisms to improve the ecological balance of intestinal microorganisms, the largest immune organ of human body, so as to promote immune tolerance. Lactobacillus salivarius has the international patent certification for reducing serum IgE allergic antibody. After continuous supplementation for more than three months, the concentration of IgE in the body is reduced, so that allergens cannot combine with IgE antibodies in the body, and a series of allergic biochemical reactions no longer occur. Therefore, probiotics can regulate allergic constitution, while drugs can only relieve symptoms, but not regulate allergic constitution. The effective combination of antiallergic drugs and antiallergic probiotics can also produce ideal rehabilitation effect.
Second, the main components of probiotics are sensitive families of interest.
1, Lactobacillus salivarius (AP-3)
The patented strain obtained anti-allergic patents in China and Taiwan Province province. After careful verification by many hospitals such as Taiwan Province National Taiwan University Hospital, it can reduce the proportion of eosinophil infiltration, alleviate inflammatory reaction and help to reduce the production of specific IgE antibody in serum. It has the potential to treat allergic tracheal diseases, such as urticaria, allergic asthma, allergic cough's disease and allergic rhinitis.
2. lactobacillus paracasei (MP- 137)
The patented strain also obtained anti-allergic patents in China and Taiwan Province provinces. Taiwan Province National Taiwan University Hospital and other hospitals have proved that it can significantly increase lung function and PEFR, and reduce airway hyperresponsiveness. Clinically, it is used to treat urticaria, eczema, allergic asthma and allergic rhinitis. The symptom score of allergic probiotics group was significantly reduced, and it has clinical improvement effect on children with respiratory allergic diseases such as asthma and allergic rhinitis.
3. Lactobacillus reuteri (GL- 104)
The patented strain also obtained anti-allergic patents in China and Taiwan Province provinces. Many hospitals, such as Taiwan Province National Taiwan University Hospital, have proved that it can increase intestinal probiotics, thus improving immune response, improving intestinal barrier function, helping to reduce the secretion of cytokine IL-5 related to allergic reaction and improving the proliferation ability of spleen cells;
4. Lactobacillus rhamnosus (F- 1) stimulates human monocyte dendritic cells to produce IL-12;
5. Lactobacillus acidophilus (lrgg- 100) is helpful to relieve inflammation and allergy;
Comprehensive function: regulating immune response, improving allergic constitution and reducing the probability of allergic reaction.
Third, the mechanism of action of sensitive family probiotics of interest.
Allergens, such as Lactobacillus salivarius and lactobacillus paracasei, can reduce the immunogen IgE in serum, effectively block the combination of allergens and immunogen IgE antibodies, and directly block the allergic biological chain from the immune source, which goes beyond the symptomatic treatment of radical allergic treatment for mast cells and basophils. Secondly, probiotics can effectively promote spleen cells to secrete IFN-γ, directly attack immune T cells, strengthen the regulatory ability of immune T cells, and ensure the most basic immune recognition function in human immune function (the ratio of T cell balance to IFN-γ is an important determinant of IgE synthesis. )。 Probiotics come into contact with a special kind of cells in the intestine, enter the blood after colonization, and produce a series of immune T cell physiological reactions by activating the cells, which can reduce the antibody-immunoglobulin IgE in human blood. Help to solve the redness, itching and pain caused by IgE-mediated allergy, and even various allergic symptoms such as bronchial contraction, asthma, rhinitis, conjunctivitis and dermatosis.
1. Allergen probiotics can prevent allergen invasion.
Probiotics can synthesize chemicals that can destroy harmful microorganisms, and can also snatch nutrients from harmful microorganisms to inhibit their growth and reproduction. Form a natural barrier for microorganisms and prevent the invasion of allergic substances.
2. Allergic probiotics improve human immunity
Probiotics can increase the number of some active immune cells (such as macrophages and lymphocytes) or immune factors (such as immunoglobulin and interferon) and enhance their activity, thus enhancing the function of immune system and improving resistance.
3. Allergic probiotics can degrade allergens.
Enzymes produced by anti-allergic probiotics degrade allergens in food, and can also promote B cells to secrete a special antibody sIgA, marking substances in the human body as harmless, and at the same time promote the regulation of the production of T cells, identify substances that are harmless to the body, quell indifferent battles and protect innocent bystanders.
1, lactobacillus reuteri and lactobacillus paracasei are patented anti-allergic probiotics, and their anti-allergic function is guaranteed.
2. The clinical and medical experimental results of antiallergic probiotic composition have been published in international journals, and the research results are outstanding.
3. It has been clinically proved by human body that Lactobacillus reuteri can effectively reduce the severity of rhinitis symptoms in allergic children by 50%, and significantly improve the respiratory tract patency index (PEFR) at night.
4. Adjusting the immune balance can not only improve the activity of Th 1, but also effectively reduce Th2 activity and IgE secretion, effectively balance the proportion of Th 1/Th2 immune cells, and completely relieve allergies.
5. The compound antiallergic probiotic strains are registered by Taiwan Province Food Industry Research Institute, which ensures the consistency of efficacy and source of antiallergic strains.
6. Anti-allergic probiotic composition The most natural and healthful functional strains of human body are screened by the most advanced biochip technology in the world. After gastric acid bile salt tolerance and colonization test, it is safe and has high survival rate.
Four. Safety of allergy prevention in children aged 0- 12;
Lactobacillus salivarius (AP-3), Lactobacillus reuteri (GL- 104) and lactobacillus paracasei (MP- 137) were isolated and purified from the digestive tract of healthy newborns, belonging to human protozoa and patented strains. The product is the first to pass the safety test in the evaluation method of "Regulating Allergy" health food by the Health Department of Taiwan Province Province. People with allergic diseases or allergies (including pregnant women, infants, lactating women, young and middle-aged, etc. ) you can take it with confidence.
Gastric acid tolerance and bile salt tolerance test;
Five strains of antiallergic probiotics, including Lactobacillus salivarius, Lactobacillus lactobacillus paracasei, Lactobacillus Roy, Lactobacillus rhamnosus and Lactobacillus acidophilus, were detected. The results showed that after the culture medium was activated, the preserved strains of antiallergic probiotics were treated with acid buffer and bile salt, and the number of bacteria was not affected by the change of choline in gastric acid, and the five strains of antiallergic probiotics were not affected by gastric acid, which proved that these five strains of antiallergic probiotics could pass the strict environment test of human digestive system.
Colonization:
The experimental results show that the five probiotics in Ximinjia Probiotics Granules belong to "strong attachment", that is, they have high colonization, can attach to the intestine and proliferate, and all of them are native strains of human body.
Verb (abbreviation of verb) academic support
1, the effect of Lactobacillus salivarius on cutaneous anaphylaxis is remarkable, and the paper "Lactobacillus salivarius has a better effect on severe atopic dermatitis in children: a double-blind, randomized, effective and safe human clinical trial" was published, and the publication: Pediatric Dermatology 20 1 1 was published, and the strain obtained the patent for antiallergic invention in China;
2. To observe the effect of probiotics on allergic rhinitis caused by dermatophagoides farinae, dermatophagoides farinae or dust: Randomized double-blind trial: Source: Indian Pediatrics; The results of 20 13 showed that the consumption of Lactobacillus salivarius significantly improved the allergic symptoms related to eyes and nose in patients with 8 weeks 12 weeks, and children with allergic rhinitis could reduce the frequency of allergic rhinitis and allergic drug use.
In order to improve the comprehensive immune regulation of allergic patients and solve the different effects of diseases and constitutions, functional strains were screened from nearly 200 blood samples for anti-allergic probiotics. After taking it, the conscious improvement effect reaches more than 90%, and the effect is more remarkable than that of single bacteria.