1. Different types
The recombinant COVID-19 vaccine developed in China belongs to recombination vaccines. This is a genetic engineering recombination vaccines technology widely used in the world, which can speed up the time compared with the traditional inactivated vaccine technology.
the American mRNA-1273 vaccine belongs to the mRNA vaccine. This is an anti-novel coronavirus messenger RNA (mRNA) vaccine, which can target the spike protein of the virus.
Second, the principle of action is different
The recombinant COVID-19 epidemic developed by China is to clone the gene fragment of the virus and then put it into bacteria for replication and expression. When there is a sufficient amount, it is extracted as antigen to prepare vaccine.
The basic principle of the mRNA-1273 vaccine in the United States is that the mRNA carrying the instruction of making antigen protein by cells is injected into human body, and then it is swallowed by human cells, and the protein manufacturing factory in the cell will produce antigen protein that can stimulate the immune system of the body according to the instruction, such as S protein of the new coronavirus, which can stimulate the body to produce antibodies to resist the virus.
Third, the time and risk are different
Compared with the recombinant COVID-19 vaccine developed in China, the mRNA-1273 vaccine in the United States can bypass the animal experiment stage and directly enter the human experiment, which will also save time and cost. Although it is extremely advanced, the risk coefficient is relatively high.
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