The German research team believes that Pfizer’s mRNA vaccine may cause autoimmune hepatitis, mainly due to the induction of cellular immunity and excessive cytotoxic T cells. The male patient who received two doses of the Pfizer mRNA vaccine was a 52-year-old man with no medical history other than hypothyroidism.
He developed jaundice 10 days after the first dose of the mRNA vaccine, and liver function tests revealed acute mixed hepatocellular, cholestatic hepatitis. The patient was hospitalized 25 days after vaccination. The patient received the second dose of BNT162b2 vaccine 41 days after the first dose. The patient developed symptoms such as fatigue and nausea 20 days after the second vaccination, and laboratory tests showed recurrence of acute mixed hepatitis. Twenty-six days after the second vaccination, the patient was referred to a tertiary care center for treatment. Many people who have received the Pfizer vaccine in the past two years, including those in the United Kingdom, Switzerland, Turkey, Japan, etc., have experienced various problems, especially cardiovascular and cerebrovascular and death problems. The U.S. Food and Drug Administration was under pressure to publish the Pfizer vaccine. Some of the vaccine review documents.
Among the more than 150 sub-documents released so far, there are 9 pages of vaccine side effects and a total of 1,291 special issues and adverse events. 380 people aged 18 to 75 were asked about side effects of the Pfizer vaccine. The results showed that the side effects of the Pfizer vaccine were stronger and symptoms worse after the second dose. In terms of age, younger people are more likely to have more severe side effects and symptoms than older people. Symptoms such as fever and fatigue are more noticeable, especially the day after vaccination. The patient underwent serology, polymerase chain reaction testing, and autoimmune serology showed mild hyperglobulinemia, borderline positivity for antinuclear antibodies, antimitochondrial antibodies, and antismooth muscle antibodies, but negative for LKM antibodies.
The 52-year-old man's symptoms were consistent with autoimmune hepatitis, researchers said. The patient received 9 mg of budesonide daily. Budesonide is a very potent topical anti-inflammatory glucocorticoid. Existing data show that the drug can improve the stability of endothelial cells, smooth muscle cells and lysosomal membranes, inhibit immune responses, and reduce antibody synthesis. Within weeks of treatment, patients' liver enzyme levels dropped and began to improve.
The research team believes that the Pfizer mRNA vaccine may cause immune-mediated hepatitis by triggering cellular immune mechanisms. The results show that T cells are the key pathogenic immune cell type in this vaccine-related immune hepatitis. The European Medicines Agency’s Pharmacovigilance Risk Assessment Committee announced that there is no evidence to support a causal relationship between the mRNA COVID-19 vaccine and autoimmune hepatitis, and there is currently no need to update the vaccine’s product information.