Effect of nmn on cells
In fact, nmn exists in human cells and is responsible for NAD+ biosynthesis and energy production. These two compounds will degenerate with age, so nmn is not enough. NAD+ is like a small tree without nutrient supply, which will wither slowly. In other words, the decrease of nmn will lead to cell degradation. However, if the NMN substance in the body can be supplemented in time, it will reverse the aging process and delay the aging mechanism.
NAD+ is a key coenzyme in every cell of the body, involving hundreds of metabolic processes. Various studies show that NAD+ concentration in the body is an important indicator of aging, which is helpful to repair damaged DNA. It is an activator of longevity gene SIRT 1, which is helpful to transform nutrients into energy and participate in various very important physiological processes as a key role in metabolism. With the increase of age, the concentration of NAD+ will decrease exponentially. Studies show that at the age of 50, the NAD+ in our body is less than 1/2. How can I replenish the lost NAD+? The researchers found that NMN can pass through the cell membrane unimpeded and recover the intracellular NAD+ level more quickly. ACMETEA W+NMN and NAD+ were degraded to NR before crossing the cell membrane. Interestingly, this degradation did not lose the ability of NMN to enhance NAD+. Extracellular enzymes (extracellular enzymes) will carry out this transformation, and they are everywhere. For example, extracellular enzyme CD73 can cleave NAD+ into NMN and AMP, or dephosphorylate NMN into NR and adenosine.
All kinds of experiments show that nmn is a substance with high metabolic activity to restore cells so far, and it is also of significance to restore cells. Because of its incredible function, it has become a market with uneven quality, so how to identify it? I'll teach you today.
Ten Core Standards of W+NMN International Quality Management
1. Quality management system: NMN must meet the inspection qualification of OULF EU law and the certification of FDA, US Food and Drug Administration. In addition to the product name, the words ACMETEA, content of each component, NMN purity, etc. should also be marked, as well as the country of origin and distribution.
2. Manufacturing process management system: Advanced manufacturing process affects the shape of NMN. Chemical extraction is not recommended to avoid chemical residue.
3. Content management system: the relative NMN content is ≥ 12000 mg/ bottle, which is directly absorbed into the small intestine, and the intestinal absorption is 20% of the gastric absorption.
4. Efficiency management system: the authenticity and purity of raw materials should be investigated.
Absorption management system: adopt intestinal absorption to improve absorption rate and absorption threshold.
6. Activity management system: The unit dose (per 100g) is converted into the number of molecules of NAD+, and NMN molecules can easily cross the cell membrane and enter the cell interior, thus increasing the human NMN content within 15 minutes and rapidly raising the level of NAD+.
7. Application scope of management system: adults (pregnant women and lactating women are prohibited).
8. Safety management system: production technology, raw material collection, basic system of Olaf safety standards, pre-factory safety inspection, strict review of microbial heavy metals exceeding the standard, and scientific production technology.
9. Raw material management system: Most NMN enterprises are certified by a single country, but at present, the management of raw materials certified by two countries is more rigorous and safe. ACMETEA W+NMN is a product with French and American certification standards.
10, transnational regulatory management system: dual supervision of "law" and "beauty". The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
Details of the Top Ten International Core Standards of W+NMN Quality Management:
A, production process management system:
Does the manufacturing process also affect the health of NMN?
The raw materials are medical grade raw materials, which are generally not used for direct oral administration;
W+NMN fermentation method+biological enzyme method: Most MNM is a chemical extraction process, which is widely used and really reduces the cost. However, chemical residues are hard to avoid, which will increase the complexity of formation and reduce the use effect in the process of transforming NAD+. The long-term accumulation of chemical residues will bring many uncertain health risks.
At present, W+NMN is produced by imitating the working process of catalytic enzymes in human body by fermentation method and biological enzyme method, which are rarely used. It is green and high quality, but the process is complex, time-consuming and labor-intensive, and the output is extremely low, so the cost of a bottle of W+NMN is at least 600 to 700 dollars/bottle.
Second, the absorption management system:
Whether the effect of NMN is obvious or not, the absorption of nutrients by ordinary people is only 10-20%, and NMN is no exception. When the purity of NMN is increased to 99%, ACMETEA W+NMN technology can stabilize the morphology of MNM in the stomach, quickly penetrate the membrane to avoid gastric acid damage, and the absorption rate can be increased by ten to twenty times. Slc 12a8 transporter in small intestine cells is responsible for transporting NMN into cells, and then it will be used by cells in various organs and tissues of the body with blood circulation, which ensures the authenticity of W+NMN 12000 clinical data.
Third, a flexible management system:
The unit dose of ACMETEA W+NMN (per 100g) is converted into the number of molecules of NAD+, and the concentration of NMN in blood gradually increases within10min. Within 30min, NMN enters multiple tissues with blood circulation, and NAD+ is synthesized in tissues, thus increasing the level of NAD+.
IV. Scope of use of management system:
1. elderly people, used to help improve various senile diseases;
2. Middle-aged people, eliminate or alleviate various sub-health problems, such as chronic fatigue, poor sleep, and decreased vision. ;
3. Stay up late, accelerate physical recovery;
4. Candidates should improve their ability to resist pressure and keep a clear head;
5. Those with higher radiation dose, such as radiologists, nurses and aircrew, improve their ability to repair genes damaged by radiation;
6. Cancer patients, help patients repair genes after radiotherapy and chemotherapy, improve immunity and accelerate physical recovery;
7. Fitness to accelerate muscle growth;
8. Athletes, improve their energy level and reaction speed;
9. drinkers, improve the ability to sober up, protect the liver and repair the genes damaged by acetaldehyde toxicity.
10. For patients with depression, increase dopamine level, change mood, increase blood supply to the brain, and relieve brain decline caused by depression;
1 1. Middle-aged and elderly women can improve skin health and delay skin aging;
Verb (abbreviation of verb) multinational supervision and management system:
W+NMN content standard, multinational supervision and management system, ACMETEA contains NMN activator, OULF has passed EU testing and FDA certification, and France and the United States have dual supervision. W+NMN meets the requirements of FDA for dietary supplement GMP, which is a set of mandatory standards for pharmaceutical and food industries. Comply with the relevant provisions of the European Food Safety Agency (EFSA), EU food supplements and EU law "OULF". The purpose is to ensure that the nutrition and health information provided to consumers on food packaging is accurate and reliable, so as to avoid misunderstanding by consumers.
Well, that's my question about "Why are the effects of nmn on cells mixed? Is there any basis for nmn to repair cells? " In fact, many functions of nmn are being unlocked by researchers, and I believe it will bring us more and more surprises in the next research. But remember, you must choose nmn products with appropriate standards. In fact, those mixed words are also because people are both eager and afraid of this thing. On the one hand, they hope it can help their health, on the other hand, they are afraid of stepping on the pit, and they find themselves waiting happily for a month.