Chen Zhicheng, a researcher at the Institute of Biomedicine of China Academy of Sciences, found that whether injured nociceptive nerve can regenerate and recover depends on a key molecule-protein Advillin, a kind of nerve cytoskeleton. If it is used as a biomarker, it can help to accurately diagnose and treat "neuropathic pain" caused by nerve injury, such as sciatica and diabetic pain.
Pain nerve regeneration is helpful to the recovery of neuropathy
Human sensory nerve cells are divided into pain nerve and non-pain nerve. Scientists have found that Advillin mainly exists in the sensory neurons of 1995, but its function is an unsolved mystery. Chen Zhicheng's team research confirmed the function of Advillin, which is responsible for guiding the axons of painful nerves to explore and regenerate around. Without it, the growth rate, activity and number of branches of nerve axon fibers will obviously decrease.
The research team also found through mouse experiments that accurately mastering the regeneration of nociceptive nerves will contribute to the recovery of neuropathic pain. The results showed that mice without ampicillin continued to have pain reaction, and the injured nerve was difficult to heal, while normal mice were cured because of the nerve regeneration and recovery in the affected area caused by ampicillin.
Nerve regeneration "correctly" slows down neuropathy.
During the experiment, Chen Zhicheng's research team accidentally observed the special behavior of a nerve cell. In the process of exploring everywhere, nerve axons will leave traces of Advillin everywhere. This special performance has become the source of inspiration for team research. By observing these legacy Advillin, we will be able to grasp the trajectory and scope of nerve cell regeneration.
Chen Zhicheng said that this research has two major contributions. First of all, the special manifestations of Advillin will be helpful to the diagnosis of neuropathic pain. At present, the team has applied for related patents. More importantly, this study will also open a new treatment direction. Through the regulation of Advillin, the nerve can be "correctly" regenerated, and the nerve injury can be fundamentally treated, thus effectively alleviating the neuropathic pain caused by it.
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