Excuse me, is "Anlufan" addictive after long-term use? Are there any side effects?
Drug name: aripiprazole tablets: aripiprazole tablets: 5mg* 10 tablets; Aripiprazole unit: box of aripiprazole price: 140 yuan; Aripiprazole (Abilify) is a new type of atypical antipsychotic, which can partially stimulate dopamine D2 receptor, and improve the deficiency of frontal lobe by stimulating D2 receptor. Another pharmacological action of Anlufan is that it has 5HT2A receptor blocking effect and 5HT 1A partial excitation effect, which can improve the negative symptoms, cognitive function and emotional symptoms of depression and anxiety. Because the drug has no obvious effect on the striatum dopamine pathway of midbrain-substantia nigra and the dopamine pathway of midbrain-pituitary infundibulum tubercle, and the drug blocks the receptor of 5HT2A, it rarely causes drowsiness or weight gain, and does not affect the prolactin level. Anlu is a patented new drug independently developed by Otsuka Pharmaceutical Co., Ltd. of Japan, and has independent intellectual property rights. It is a landmark new generation of antipsychotic drugs. It was first listed in the United States in the fourth quarter of 2002, and it is mainly used for the treatment of schizophrenia in clinic. In 2003, it sold 500 million US dollars in the United States, and in 2005, it reached 654.38 billion US dollars. In 2006, it still maintained a growth rate of 50%. Anlufan is sold by Otsuka and BMS***, and its global sales in 2008 was $21.50 billion, ranking first in the growth rate of antipsychotics. At present, Anlufan has been used clinically in more than 50 countries such as the United States, Europe, Japan and Asia. Anlupan has a very broad application prospect in the drug treatment of mental system. Anlufan can not only treat schizophrenia, but also has obvious curative effect on patients' positive symptoms, negative symptoms and depression and anxiety symptoms. In the United States, it is also approved by FDA for the treatment of bipolar disorder-manic episode and refractory depression. Not long ago, two Japanese companies, Bristol-Myers Squibb and Otsuka, announced that two new amraphane dosage forms (aripiprazole tablets) had been launched, namely, a tablet with a specification of 2 mg and an oral solution with a concentration of 1 mg/ml at room temperature. The dosage forms of Anlufan are tablets, orally disintegrating tablets, oral liquid and intramuscular injection. At present, it is to make Anlufan a first-line drug in the field of mental illness treatment to meet clinical needs. Schizophrenia is the most common chronic debilitating mental illness, and nearly 1% people suffer from it for life. Schizophrenia disturbs patients' normal social life, including clear thinking, emotional control, decision-making and interpersonal relationships. This disease is common in people who have just entered adulthood. Positive symptoms are mainly fantasies and hallucinations, while negative symptoms are mainly indifference, lack of interpersonal communication and lack of passion. Administration and dosage: Adults: oral, once a day. The initial dose of aripiprazole is 10 or 15mg/ day, which is not affected by eating. Systematic evaluation showed that the clinical effective dose range of aripiprazole was 10 ~ 30mg/ day. The curative effect of high dose is not better than that of low dose 10mg or 15mg/ day. Dose should not be increased within 2 weeks (the time required for the drug to reach steady state). After 2 weeks, it can be adjusted according to the individual efficacy and tolerance, but the speed of administration should not be too fast.