Patent number zl20 12 10039506.4

This is an invention patent, and its name is: an extraction method of toad thiazole. The invention discloses a method for extracting bufothiazine, which specifically comprises the following steps: cleaning dried bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo bufo buf Passing the water extract through macroporous resin column, eluting with water, gradient eluting with one or more organic solvents selected from ethanol, methanol and acetone and water as eluent, collecting the eluted part, concentrating under reduced pressure, drying, separating by silica gel column chromatography and ODS column chromatography, combining fractions of Toxofenadine, and crystallizing to obtain pure Toxofenadine. The bufothiazole obtained by the invention has high purity and yield, simple process and easy mass production.