Since studying for a master’s degree in 1994, he has been engaged in the immunopharmacology of traditional Chinese medicine and the research and development of new drugs. The title of the master's thesis is: Research on the immunomodulatory and anti-tumor effects of American ginseng polysaccharides. It is confirmed that the isolated polysaccharide component can play an anti-tumor effect by improving the body's immune function. The title of the doctoral thesis is: Isolation, purification and anti-inflammatory mechanism of bee venom polypeptide. The bee venom anti-inflammatory component BVI-2H was separated through extraction, ultrafiltration, gel chromatography, affinity chromatography, HPLC and other methods, and screened through activity experiments to obtain bee venom anti-inflammatory component BVI-2H. It has also been proven that BVI-2H can exert anti-inflammatory effects by inhibiting the functions of T cells and macrophages, the production of IL-1, TNFα and other cytokines, the cell cycle and the phosphorylation of p38 protein kinase and IκBα protein; and can effectively Inhibits adjuvant-induced paw swelling in rats. The title of the postdoctoral research report is: Isolation and purification of the active ingredients of Scutellaria baicalensis and research on its anti-inflammatory mechanism. The methanol extract of Scutellaria baicalensis SBM was isolated by ultra-high pressure method, and it was confirmed that SBM can interfere with cell functions, inhibit the synthesis of COX-2, PGE2, IL-1β, and COX-2 protein expression induced by LPS; inhibit adjuvant arthritis and keratitis Models of acute and chronic inflammatory reactions such as forkine gum and formaldehyde-induced foot swelling in rats. This research content has been patented. The scientific research results are as follows: Application for the National Natural Science Foundation: Research on the anti-rheumatoid arthritis mechanism of active ingredients of baicalin (responsible for the overall design and main research work of the project, project approval number: 30371334); application for the Hainan Provincial Natural Science Foundation One: Research on the anti-tumor effect of baicalin (project leader, project approval number: 80413); one patent application: Extraction of baicalin and its application in anti-inflammatory pharmaceuticals (grant number: 03127601.6).
Books and papers
1. "Edge Immunology", Science Press, 2002, co-editor;
2. Isolation and purification of BVI-2H from bee venom and analysis of its biological action Chinese Science Bulletin, 2002; 47(11): 910;
3. Isolation, purification and biological activity of BVI-2H, a new polypeptide component of bee venom, Science Bulletin, 2002, 47: 198;
4. Effects of new bee venom polypeptide BVI-2 on T cells and THP-1 cells, Chinese Journal of Immunology, 2000, 11: 583;
5. Study on the isolation properties and activity of American ginseng polysaccharide 5-2, Chinese Pharmaceutical Journal, 1998, 33: 497;
6. Effects of American ginseng polysaccharide component (PPQ-1) on the synthesis of cytokines by mouse spleen lymphocytes, Chinese Pharmacological Bulletin, 1997, 13:76;
7. Effects of American ginseng polysaccharide on the transformation function of mouse spleen lymphocytes, Journal of Bethune Medical University, 1997, 3: 236.