bkk3xwfb1 jyrmvsw3y39yextpg 75h jujube and so on, which was created by Zhang Zhongjing in Han Dynasty. It has the effects of nourishing yin and blood, nourishing yang, stopping palpitation and restoring pulse, with pulse < P > QWSE9DG51XU1U9SQAJ91WNRDEPAS9 as the key point of syndrome differentiation and treatment. At present, it is clinically used to treat arrhythmia, viral myocarditis and other diseases < P > N5AbeewQV5424WNMY3B WW4M24CYK3H6g, and the curative effect is remarkable. In recent years, the pharmacological research on Zhigancao decoction has been strengthened, which is briefly described below.
umfjcfhwsk8dcb8nn1hr647gsarawq7 ■ antiarrhythmic
hnfqe4q6ffhrccfaetwcx29q8fqav7 Zhigancao decoction can significantly reduce ventricular premature beats and ventricular tachycardia induced by ligating the anterior descending branch of left coronary artery in rats, and make the total incidence of arrhythmia
xrnx6Gf5w17DRT evdhr6x8w78PSUxh. Zhigancao decoction has obvious protective effect on arrhythmia caused by chloroform. The experiment of oral administration of
bsjhewadckgkk4kctwy4xygd7ddnhkh in rabbits showed that it had no obvious effect on the heart rate and electrocardiogram of rabbits after rapid intravenous injection of epinephrine hydrochloride, and
7muwn1f9wxk5bu3cbqnwxhtca 45b Qu4 did not affect the occurrence of arrhythmia, but it could significantly shorten the duration of arrhythmia, and at the same time, it was
ymn7ahwwxj4V41gwhen the normal heart rhythm recovered. Jiawei Zhigancao Decoction can obviously shorten the duration and severity of experimental arrhythmia caused by Radix Aconiti extract in rabbits < P > 88 cuswkecbqasmaascdsn49 nwxpcaj5n. Jiawei Zhigancao Decoction injection can significantly improve the short-term cardioversion rate of sinus heart rate. Trace element analysis of micro
py3r69nn5drdgfa9 r821Nbapefbesn shows that Zhigancao decoction series is rich in magnesium, zinc, selenium, manganese, etc., among which magnesium can directly strengthen the heart and restore pulse
cm HK B1 NMCY84S6 KMW48HF9C8N9Utuys, and zinc, selenium and manganese can nourish yin and tonify kidney, which has an indirect effect of restoring pulse.
cv52xtuw9rw7fqnr 96txf93y7qg5pu ■ Anti-myocardial ischemia-reperfusion injury
3t55xanb54a 9PGB31VCNNDMDJR4YV6 research found that Zhigancao decoction can reduce the incidence of arrhythmia induced by myocardial ischemia-reperfusion injury in rats,
WTQ941A5UGXWJKK4MS6KECKDSBR48 was significantly reduced. It can also significantly reduce the malondialdehyde content of lipid peroxide product < P > 9JYU GCW 67GWE 31SGQWY4S9 QG6A GS95AU in reperfusion myocardium, and enhance the activity of superoxide dismutase.
the effect of 92d5pdv6pb w4 twnndnhfcq277jax ■ on isolated myocardium
yu1wbckg7mmftuhvu7srkr11y6x42x7 isolated myocardium of rats and guinea pigs was used as the research object. It is found that Zhigancao decoction can increase the concentration of adrenaline threshold < P > uasda4esevyjvhamudeyjwwutx 69m9b, and obviously inhibit the autonomy and excitability of isolated guinea pig left atrium and papillary muscle induced by adrenaline. < P > 96U1FP33DASP6P7D4 Rg5G1F2J3NT2G can prolong the refractory period of atrial function. When glycyrrhizic acid, ginsenoside and Ophiopogon japonicus were formulated at .348, .1 < P > 71x25E778A6FQ1D1sky BT 48XTUK544 and .12mg/ml, the refractory period of left atrial function could be obviously prolonged.
8U3HRE6J48W5TT8DMH92TPN2R89DM18 ■ Effect of nourishing yin and enriching blood
R4 QHR 94W44MR 53CGQMRW3GU7BS49C intravenous injection of Zhigancao Decoction can reduce the incidence of arrhythmia in healthy and yin-deficient rats, and reduce the normal rate of heart rate loss
46k2GGFDN9NK8JCF83QXRW9FX5TG. By measuring the total number (rbc) and hemoglobin (hb) of red blood cells < P > xpmxvaxebbmhfbx726Hetpc3B9yfe before and after drug administration in mice, it is found that Zhigancao decoction has a good blood-enriching effect, and its weight is < P > MkmcJPDWC2C9Exhyvy 9257MJ9Nvgua is used for nourishing yin, benefiting qi and enriching blood. The drug is self-satiating, which often leads to poor appetite and affects digestion and absorption. Some white mice < P > UA28Y1AUYS8V5 D6CYWA 6 PXF1 T35 may have abdominal distension. It is suggested that attention should be paid to self-satiety when taking medicine, and the methods of shortening the decocting time and reducing the concentration of medicine < P > J9TDGCKG3W512826CWNY6M9UK3RWX4e can be used to alleviate and eliminate the adverse effects.
h4bqk8m996xu14SMS 8gu5s ax 62gjee2j ■ Anti-aging effect
Rt9 Eye V2QQ 44g6tt72R5tfb1u55Sjqg Zhigancao Decoction is a tonic prescription, which can enhance the activity of superoxide dismutase (sod) in mice. Reduce
the content of lipid peroxide (lpo) in cmc1nvj1hcpn833butt8mj7px386U5hb, and at the same time, promote metabolism, enhance the excitability of cerebral cortex,
2q2tkmr9tb3vqby6dbvygtdh3utqpf and improve the system functions of respiration, circulation, digestion and hematopoiesis. Therefore, Zhigancao Decoction is not only used for arrhythmia, < P > NMTMFB 22QCV 77FHRBVMQHWHK 7VM1S5 can also improve body function, enhance immunity, enhance vitality and delay the aging process. Zhigancao decoction is also
q878w6bmg8r9avruw29sw1 DSR t98ta, which can resist hypoxia and affect the metabolism of nucleic acid and protein.