Astragalus membranaceus is sweet in taste and warm in nature, and enters spleen, liver and kidney meridians. Astragalus polysaccharide contained in Astragalus membranaceus can reduce blood sugar level, and its mechanism is related to the levels of IRS- 1, InsR, P 13-K in renal tissue, which can promote the differentiation of adipocytes, improve insulin signal transduction and increase the sensitivity of tissues to insulin. Polysaccharides isolated from the roots of Astragalus membranaceus have the function of regulating blood sugar in two directions.
Huanglian Huanglian berberine, the main component of Huanglian, has the functions of lowering blood sugar, correcting lipid metabolism disorder, obviously reducing hyperinsulinemia, improving abnormal glucose tolerance of diabetes, reducing lipid peroxide in liver, improving the activity of superoxide dismutase in liver and playing an antioxidant role. Berberine in Rhizoma Coptidis can increase insulin sensitivity, reduce serum FFA level, reduce body weight, increase cell membrane insulin receptor density, and improve the relative shortage of insulin receptors in visceral obesity.
Ganoderma lucidum polysaccharide in Ganoderma lucidum can increase the concentration of plasma insulin, increase the utilization of glucose by surrounding tissues, and improve the utilization of glucose by strengthening the activities of various key enzymes involved in liver glucose metabolism. In addition, oral administration of Ganoderma lucidum polysaccharide can reduce the hyperglycemia of diabetes, improve the insulin level and play a role in lowering blood sugar.