The application of self-developed detection kit and automatic nucleic acid extraction technology greatly shortened the detection time of viral nucleic acid, and quickly formed the daily average 1000 people's nucleic acid detection ability. "It played a very key role in the prevention and control of the Wuhan epidemic at that time." Chen Wei said. Although the improvement of nucleic acid detection ability makes the virus "difficult to hide", vaccines are still needed as the "ultimate weapon" to eliminate the plague in COVID-19.
On the front line of anti-epidemic, Chen Wei led the team to fight side by side with the rear scientific research base, and launched a charge to the development of vaccines in COVID-19. On March 16, the recombinant COVID-19 vaccine developed by Chen Wei's team was approved to start clinical trials. On April 12, the second phase clinical trial of vaccine began, which was the first COVID-19 vaccine variety to enter the second phase clinical trial in the world at that time.
The related test results have been published online in the international academic journal The Lancet. At present, the vaccine has been authorized by the national invention patent, and the third phase of international clinical trials is progressing in an orderly manner. In a recent media interview, Chen Wei revealed that the recombinant COVID-19 vaccine can effectively cover the mutated COVID-19.
In addition, Chen Wei's team also found the first highly effective neutralizing monoclonal antibody against spinosad N-terminal domain, which provided a powerful candidate drug for the treatment of COVID-19 and a brand-new idea for studying the mechanism of COVID-19. At 22: 00 Beijing time on June 22nd, the international academic journal Science published the research results online.
"At this time, it should be said that everything that can be thought of and done is used." Chen Wei lamented that the scientific research team has been in a state of "training for thousands of days and using soldiers for thousands of days". This trip to Wuhan is not the first time that she has led a team to "hold hands" with the deadly virus.
When SARS was raging in 2003, Chen Wei and his research group entered the biosafety laboratory overnight to study the SARS virus. The "recombinant human interferon ω" successfully developed by the team has a good protective effect on the attack of SARS virus. * * * 14000 medical staff used "recombinant human interferon ω spray" and no infection occurred.
In 20 14, a large-scale Ebola outbreak broke out in west Africa. Chen Wei led the team to explore the disease in the African continent, developed the world's first new genotype vaccine against Ebola virus, and achieved zero breakthrough in overseas clinical trials of China's self-developed vaccine. Plague, anthrax and Ebola have been enlisted for 29 years. Chen Wei's research objects are diseases that ordinary people can't avoid, and they are called "the devil's subject" by colleagues. It is the long-term experience of "dancing with poison".
During the COVID-19 epidemic, she and her research team were able to develop a vaccine and put it into clinical trials as soon as possible. Even so, in Chen Wei's view, the experience of fighting the COVID-19 epidemic is somewhat different from the past. In an interview, she said: "The determination of a team, confidence in their own technology and understanding of domestic and foreign laws and regulations are where we can go today."
Chen Wei once said that in the field of biosafety, you don't know what will happen in the future. In her view, the guarantee of biosafety should not only "be able to cope with known pathogens", but also "be able to cope with future epidemics". During the two sessions of the National People's Congress this year, Chen Wei, as a member of the Chinese People's Political Consultative Conference, put forward a proposal to build a national biosafety science and industrial innovation center.
I hope that the innovations in the field of biosafety can quickly benefit ordinary people. "As a military medical researcher, I especially hope that our scientific research' warship' can ride the wind and waves and be stable and far-reaching." Chen Wei said that she and the research team will continue to work hard for this. "This is an honor and a responsibility. Only in this way can we live up to this era and live up to our mission. "