COVID-19 is an infectious disease, which should be controlled according to Class A infectious diseases. Previously, there were loopholes in the protection of criminal law, and it was only stipulated that "causing the spread of Class A infectious diseases or having serious danger of spreading" belonged to the category of the crime of obstructing the prevention and control of infectious diseases. Amendment (XI) to the Criminal Law clarifies that infectious diseases such as COVID-19, which are legally determined to take measures to prevent and control Class A infectious diseases, fall within the adjustment scope of Article 330 of the Criminal Law, and increases the sale and transportation of articles contaminated by infectious disease pathogens or possibly contaminated by infectious disease pathogens in epidemic areas. Refusing to implement the prevention and control measures put forward by the people's governments at or above the county level and the disease prevention and control institutions according to law, concealing the itinerary and trajectory, or going out privately in violation of the isolation regulations may constitute a crime. In judicial practice, governments at all levels and relevant departments require personnel not to gather, provide nucleic acid test reports and truthfully report epidemic prevention and control measures. Violation of these regulations will cause the spread of novel coronavirus or have a serious risk of spread, so it is suspected of constituting a crime of obstructing the prevention and control of infectious diseases, and criminal responsibility should be investigated according to law.