Principles of cas9 gene editing

Principle of cas9 gene editing: The CRISPR/cas system is embedded into the genome, so that CRISPR nucleic acid and Cas protein can be combined with specific DNA sequences, thus achieving the purpose of gene editing.

CRISPR-Cas9 is a gene therapy, which can treat many diseases through DNA splicing technology. From 2065438 to March 2007, the British journal Nature Communication published an important research achievement in genetics, and CRISPR-Cas9 system can be used to save blind mice.

CRISPR-Cas9 is an adaptive immune defense formed by bacteria and archaea in the long-term evolution process, which can be used to fight against invading viruses and foreign DNA. CRISPR-Cas9 gene editing technology is a specific DNA modification technology for the target gene, which is also a cutting-edge method used in gene editing.

Gene editing technology based on CRISPR-Cas9 shows great application prospect in a series of application fields of gene therapy, such as hematological diseases, tumors and other genetic diseases. This technical achievement has been applied to the precise genome transformation of human cells, zebrafish, mice and bacteria.

Patent authorization

On April 5, 20 14, 14, the first patent authorization of CRISPR was obtained from the US Patent and Trademark Office. Patents include the use of CRISPR in eukaryotic cells or any nucleated species. This means the right to use CRISPR on all living things except bacteria, including mice, pigs and people.