After nearly 50 years of development, my country's β-lactam antibiotics have formed a complete production system. In 2012, almost all beta-lactam antibiotics (except those within the patent period) can be produced in my country at very low cost. Penicillin production ranks among the top in the world, and a large number of them are exported to the international market; cephalosporin antibiotics are basically self-sufficient. , and can also win some exports.
In 2012, my country was able to produce all intermediates supporting β-lactam antibiotics on its own. Except for the mother core 7-ACA and 7-ADCA of semi-synthetic antibiotics, which needed to be partially imported, all side chains All intermediates can be produced and exported in large quantities.
Take phenylacetic acid, the main supporting intermediate of β-lactam antibiotics, as an example. There are nearly 30 phenylacetic acid manufacturers in my country, with a total annual production capacity of about 20,000 tons. However, most enterprises are small in scale, with the largest producing 2,000 tons per year, and most others producing hundreds of tons per year. In 2003, the total domestic demand for phenylacetic acid was approximately 14,000 tons, and the consumption structure was as follows: penicillin G accounted for 85%, other pharmaceuticals accounted for 4%, spices accounted for 7%, and pesticides and other fields accounted for 4%.
With the development of domestic spices, pharmaceuticals, pesticides and other industries, the demand for phenylacetic acid will further increase. It is estimated that by 2005, my country's pharmaceutical industry will consume approximately 14,000 tons of phenylacetic acid, the pesticide industry will consume 500 tons, and the spice industry will consume approximately 2,000 tons. Coupled with consumption in other fields, the total domestic demand for phenylacetic acid is expected to reach 18,000 tons in 2005.