Development of Biomarkers for Diagnosis of Kawasaki Disease in Children in Taiwan Province Province.

Kawasaki disease in children is the main cause of acquired heart disease in children. At present, it is recognized that the only effective drug to treat acute Kawasaki disease is high-dose serum immunoglobulin injection (IVIG). However, 15% of the sick children are complicated with coronary artery aneurysm because of their special constitution and poor antipyretic effect. Recently, the IP- 10 biomarker developed in Taiwan Province Province has two characteristics: high sensitivity and high specificity, which will become a weapon for early diagnosis of Kawasaki disease in children. Only when five symptoms appear at the same time can Kawasaki disease be judged as a disease of systemic arterial inflammation. Common symptoms are: (1) high fever for more than five days; (2) red-eye conjunctivitis; (3) dry lips, broken skin and bleeding; (4) rashes of various shapes appear all over the body; (5) Cervical lymphadenitis; (6) Symptoms such as finger and sole swelling. Five of these six symptoms must appear at the same time to judge the disease. If the treatment opportunity is delayed, the sick children will face the risk of complications of coronary artery aneurysm. IP- 10 is a sharp weapon for early detection of Kawasaki disease. In recent years, the Children's Hospital of China Medical University and other medical centers have cooperated with the National Genome Medicine Research Center of China Academy of Sciences, and finally found a new biomarker for early detection of Kawasaki disease-IP-10 in protein, published in famous medical journals such as Nature and Circulation Medicine, and even obtained patents from the United States and Japan, which will be popularized soon. IP- 10 can also evaluate the therapeutic effect of Kawasaki disease. Dr. zhang, director of the Department of Pediatric Cardiology, Children's Hospital affiliated to China Medical University, said that IP- 10 biomarkers have three characteristics: (1) Early diagnosis (within 5 days of patients' fever): As Kawasaki disease is more common in children under 5 years old, early diagnosis is quite helpful. For doctors, it can effectively identify the high-risk groups of Kawasaki disease and strengthen their care. For parents, it can effectively relieve their psychological pressure. (2) Highly reliable diagnosis basis (5 days after fever): After 5 days of fever, the biomarker has a high recognition degree, which is helpful to distinguish cases with extremely similar clinical manifestations, especially Kawasaki disease patients with incomplete symptoms. There is even the possibility of assisting clinical diagnosis. (3) The therapeutic effect of Kawasaki disease can be evaluated: because the biomarker of the present invention is highly sensitive to the success of immunoglobulin therapy, it can provide help in monitoring the therapeutic state of Kawasaki disease. Subscribe to the health Aloha audio-visual channel, read health knowledge more easily, and pay attention to your health every day! Line @ ID: @:/supply/article/26807/Taiwan Province Province has developed a sharp tool for diagnosing Kawasaki disease in children Keywords: Kawasaki disease, acquired heart disease, serum immunoglobulin injection, IP- 10, Zhang, H.