2. The third prize of Jiangsu Science and Technology Progress in 2006 was "Detection of Micrometastasis in Peripheral Blood of Patients with Gastrointestinal Malignant Tumors and Development and Application of Micrometastasis Gene Chip".
3. The third prize of Science and Technology Award of China Society of Integrated Traditional Chinese and Western Medicine in 2006 was "Basic and Clinical Research on Enhancing Chemotherapy Sensitivity of Hematological Tumors by Integrated Traditional Chinese and Western Medicine".
4. In 2009, "Research and Application of Multi-methods Reversing Multidrug Resistance in Leukemia" won the second prize of Science and Technology Progress Award of the Ministry of Education.
5.20 1 1 "Study on Identification and Reversion of Tumor Drug Resistance Based on Nanobiotechnology" won the second prize of Science and Technology Progress Award of the Ministry of Education. 1., Zhang Renyun, Lv Gang, Wu Chunhui,, Gao Feng,, Chen Baoan, Fu Degang, Li,
Guan zhiqun. A targeted magnetic nanometer medicine for treating leukemia and its preparation method are provided. Patent number: ZL 2005 1 0040657.438+0.
2. Wang Xuemei, Wu Chunhui, Song Min, Li Jingyuan, Zhang Renyun, Wu Dehong, Hong Yan, Gu Zhongze and Chen Baoan. Organic gold
And belongs to a preparation method of a carborane targeted nano preparation and a targeted preparation. The patent number is ZL 2006 1 0096423.3. 1. The general project of National Natural Science Foundation: Study on Mechanism of Tetrandrine and Coxifene Reversing Multidrug Resistance in Leukemia Cells (No.:3990832, duration: 2000.6438+01-2002.12) has been completed.
2. A major project in Nanjing: non-myeloablative hematopoietic stem cell transplantation for leukemia (No.:YQ0008, research period: 200 1-2004) has been completed.
3. The Science and Technology Development Fund of Jiangsu Provincial Health Department: The purification effect of biotherapy on chronic myeloid ASCT in vitro (No.:H200344, research period: 2003-2005) has been concluded.
4. The key project of Zhong Da Hospital of Southeast University: Non-myeloablative hematopoietic stem cell transplantation for hematological diseases (No.:2003YJ02, research time: 2003-2005) has been completed.
5. The special research fund for doctoral programs in colleges and universities: * * Study on the mechanism of reversing multidrug resistance in malignant hematological diseases by polytetrandrine and magnetic Fe3O4 nanoparticles (No.:20070286042, research period: 20-2008-20 10/0) has been completed.
6. The general project of the National Natural Foundation of China: * * Study on the Mechanism of Tetrandrine Polymerized Magnetic Nanoparticles and Chemotherapeutic Drugs Reversing Multidrug Resistance in Malignant Hematological Diseases (No.:30740062, research duration: 2008-2009) was completed 7. General Program of National Natural Science Foundation: Study on Mechanism of Reversing Multidrug Resistance of Malignant Hematological Diseases by Magnetic Nanoparticles Fe3O4 * * * Adriamycin and Tetrandrine 5- Bromide (No.:30872970, research year: 20-200911).
9. The sub-project of National High-tech Research and Development Plan (863 Plan): Research and development of ultra-sensitive nano-porous biosensor (No.:32007AA022007, research period: 2009-20 1 1) has been concluded.
10. Sub-topic of National Key Basic Research and Development Plan (973 Plan): Research on sensing and imaging method based on biomimetic molecular recognition and its system design (No.:20 10CB732404, research period: 2015, 2009) is under study.
1 1. The sub-project of National Science and Technology Support Plan (Eleventh Five-Year Plan): Study on standardized diagnosis and treatment strategy of myelodysplastic syndrome (No.:2008BAI6 1B02, research duration: 2008-20 10) has been completed.
12. The general project of the National Natural Foundation of China: the design of chemotherapeutic drugs, traditional Chinese medicines and transferrin nanocarriers and the study on the mechanism of drug resistance reversal in leukemia (No.:8 1 170492, research period: 20 12-20 15) is under study.
13. The sub-project of National High-tech Research and Development Plan (863 Plan): Development of low-cost detection system for biomarker detection (No.:20 12AA022703, research year: 20 12-20 16) is under study.
14. the general project of the national natural fund: development of platelet targeted drug delivery system and research on its anti-leukemia effect (No.:8 1370673, research period: 20 14-20 17) is under study.
15. The key medical project of Science and Technology Department of Jiangsu Province: standardized treatment of relapsed and refractory leukemia in Jiangsu Province (No.:BL20 14078, research period: 20 14-20 17) is under study. Anti-tumor effect of DMSA modified Fe3O4 magnetic nanoparticles combined with arsenic trioxide and adriamycin on Raji cells. Biomedical nanotechnology 2014; 10(2): 25 1-26 1.
2.ChangH, Wang X, Shiu, Zhu Y, Wang J, Li Q, Chen BA *, etc. Study on oxidative stress of tumor cells induced by hydrogen peroxide using graphene, gold and poly (toluidine blue O) layer-by-layer assembled membrane sensor. Biosensor & bioelectronics 2013; 4 1: 789-794.
3. Reversal effect of 3.Fe3O4 and wogonin magnetic nanoparticles on multidrug resistance of K562/A02 cells. int J nano medicine 20 12； 7: 2843-2852.
4. Synergistic effect of Fe3O4 nanoparticles and gambogic acid on phosphatidylinositol 3- kinase /Akt/Bad pathway in LOVO cells. int jnano medicine 20 12； 7: 4 109-4 1 18.
5. Gann, Zhu X, Zhang H, Wang X, Zhou X, Gu J, Chen Ba *, etc. Relationship between methylenetetrahydrofolate reductase gene polymorphism and hematological malignancies. clin lab 20 14； 60(5): 767-774.
6.JinN, Malcherek G, Mani J, Zurleit R, Schmitt A, Chen BAet et al. Ivermectin inhibits cytomegalovirus-specific CD8(+)T cell Leuk lymphoma 2014; 55(5): 1 144- 1 150.
7.LiK, Chen BA*, Xu L, Feng J, Xia G, Cheng Jet al. Reversal effect of magnetic fe3o 4 nanoparticles loaded with cisplatin on multidrug resistance of A549/DDP lung cancer cells. Int J nanomedicine 2013; 8: 1867- 1877.
8. Liang, Li Jun, Sun Bo, Li Song, Lu Li, Rebecca, Chen Ba, etc. Gene sequencing reveals the complex mechanism of abnormal regulation of microRNA in colorectal cancer. IntJ Oncology 2014; 45(2): 603-6 10.
9.LuX, Zhu A, Cai X, Jia Z, Han W, Ma L, Chen Ba * et al. The role of NKG2D in cytokine-induced killer cells against multiple myeloma cells. Cancer Biotherapy 2012; 13(8): 623-629.
10. Migration of dendritic cells labeled with synthetic superparamagnetic iron oxide in vivo. Int J nanomedicine 2011; 6: 2633-2640.
1 1.RenY, Zhang H, Chen BA*, Cheng J, Cai X, Liu Ret, etc. Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia overcome multidrug resistance. int J Nano Medicine 2012; 7: 226 1-2269.
12.SongG, Gu L, Li J, Tang Z, Liu H, Chen BA*, etc. Serum MicroRNA expression profile predicts the response of patients with diffuse large B-cell lymphoma to R-CHOP therapy. Ann Hematol 20 14.e-pub published in advance 20 14/05/27.
13. Up-regulation of tissue inhibitor of metalloproteinase -2 promotes invasion of nude mice 1 cells. Leuk lymphoma 2013; 54( 12): 2707-27 1 1.
14. Wang, Zhang H, Chen Y, Shi F, Chen Ba *. Magnetic Fe(3)O(4) nanoparticles loaded with gambogic acid inhibit the proliferation and migration of Panc- 1 pancreatic cancer cells by inactivating transcription factor ETS 1. int J nano medicine 20 12； 7: 78 1-787.
15. Wang Fang, Zhang Wei, Guo Lei, Bao Wei, Jin En, Rui Liu, Chen Ba *, etc. Gambogic acid inhibits the expression of hypoxia inducible factor-1α/ vascular endothelial growth factor in multiple myeloma cells by inhibiting phosphatidylinositol 3- kinase /Akt/ mammalian rapamycin. Cancer SCI 201. Electronic publications before 20 14/06/04.
16. Wang, Zhang, Chen Ba *, Xia, Wang, Cheng, etc. Effects of magnetic nanoparticles on apoptosis and cell cycle of Raji cells induced by wogonin. int J nano medicine 20 12； 7: 789-798.
17. Wang X, Wang X, Gao S, Zheng Y, Tang M, Chen Ba *. Solid-state electrochemiluminescence sensing platform for catechol based on novel luminescent composite nanofibers. Taranta 2013; 107: 127- 132.
18. Wen, Jiang, Chen, Zhao, Yi, Yang, Chen Ba, etc. Folic acid modified magnetic nanoparticles combined with 100 Hz magnetic field selectively induce apoptosis of BEL-7402 cells. Journal of Nanomedicine 2014; 9: 2043-2050.
19.XPC gene polymorphism provides prognostic information for acute myeloid leukemia. IntJ hematology 2012; 96(4): 450-460.
20. Xu Ping, Li Jun, Chen Ba *, Wang X, Cai X, Jiang He, etc. Real-time neurotoxicity analysis of Fe3O4 nanoparticles combined with daunorubicin on rat brain. Biomedical nanotechnology 2012; 8(3): 4 17-423.
2 1. Xu Ping, Li Jun, Shi Lei, Selke M, Chen Ba *, Wang X. Synergistic effect of functionalized cadmium-tellurium quantum dots combined with gambogic acid on labeling and proliferation inhibition of hepg 2 cells. int J nano medicine 20 13； 8: 3729-3736.
22. Xu Yong, Rebecca, Li Xiaomei, Huang Qiang, Chen Wei, Rui Liu and Chen Ba *. In vitro release of fenofibrate nano-suspension and its correlation with intestinal absorption and absorption kinetics in rats in vivo. Pharmaceutical development industry pharmaceutical 2014; 40(7): 972-979.
23. Yang, Chen Ba *, Pei X, Shangguan Fan. Multiplex analysis of multidrug resistance gene expression in tumor by photon suspension chip technology. The analyst 2012; 137( 14): 3343-3348.
24. The daunorubicin-titanium dioxide nanocomposite is an intelligent pH-responsive drug delivery system. int J nano medicine 20 12； 7: 235-242.
25. Zhong, Wu Jun, Chen Ba *, Ma, Cao Hong, Wang Zete et al. Study and analysis of single nucleotide polymorphisms of Janus kinase/signal transducer and activator of transcription gene in leukemia. Leuk lymphoma 2012; 53(6): 12 16- 122 1.
26. Zhang, Chen Ba *, Jiang H, Wang CL, Wang HP, Wang Xiaomei. Multi-model cancer treatment strategy mediated by ZnO nanorods. Biological materials. 20 1 1; 32(7): 1906- 14.
27. Chen Ba *, Wu WW and Wang Xiaomei. Magnetic iron oxide nanoparticles for targeted tumor therapy. curr cancer drug Targets 20 1 1； 1 1(2): 184-9.
28. Zhang, Jiang H, Sun Fangfang, Wang HP, Zhao J, Chen Ba *, Wang Xiaomei. Rapid diagnosis of multidrug resistance in cancer by electrochemical sensor based on carbon nanotubes-drug supramolecular nanocomposites. Biosens bioelectronics 20 1 1; 26(7):336 1-6.
29. Song M, Zhang RR, Dai, Gao F, Chi H, Lu G, Chen Ba, * Wang Xiaomei. Nanoparticle titanium dioxide combined with ultraviolet radiation inhibits multidrug resistance in vitro. Biomaterials, 2006; 27(23):4230-8.
Chen Ba *, Yin L, Cheng J, Ding, Gao C, Sun, Zhao G, Wang J, Bao W, Xia GH, Gao F and Wang Xiaomei. Effects of D, l- threo-1- phenyl -2- decylamino -3- morpholino-1- propanol and tetraline on the reversal of multidrug resistance in K562/A02 cells. Hematology.2011; 16( 1):24-30.
3 1. Wu Weihua, Chen Ba *, Cheng Jun, Wang Jun, Xu, Liu Lijun, Xia Guohua, Wei Hui, Wang Xiaomei, Min Yang, Yang Lijun, Zhang Yong, Xu Gang, Li Jun. Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of malignant hematological diseases. International Journal of Nanomedicine. 20 10; 5: 1079-84.
32. Wang Jun, Chen Y, Chen Ba *, Ding, Xia GH, Gao C, Cheng Jun, Jin N, Zhou Y, Li Xiaomei, Tang M, Wang Xiaomei. Pharmacokinetic parameters and tissue distribution of magnetic Fe _ (3) O _ (4) nanoparticles in mice. International journal of nanomedicine. 20 10; 5:86 1-6.
33. Chen Ba *, Mao P, Cheng J, Gao F, Xia GH, Xu, Shen Hailin, Ding, Gao C, Sun Q, Chen W, Chen N, Liu Lijie, Li Xiaomei and Wang Xiaomei. Magnetic fe3o 4 nanoparticles copolymerized with daunorubicin and MDR 1 shRNA expression vector reversed multidrug resistance of leukemia cells. International journal of nanomedicine. 20 10; 5:437-4.
34. Chen Ba *, Jin N, Wang J, Ding, Gao C, Cheng J, Xia GH, Gao F, Zhou Y, Chen Y, Zhou G, Li Xiaomei, Zhang Y, Tang M and Wang Xiaomei. Effect of Fe _ (3) O _ (4) magnetic nanoparticles on immune function of normal ICR mice. International journal of nanomedicine. 20 10; 5:593-9.
35. Zhang, Jiang H, Wang Xiaomei and Chen Ba *. Biocompatible nanomaterials reverse multidrug resistance of tumor. Mini Rev medical chemistry. 20 10; 10(8):737-45.
36. Zhong, Chen Ba *, Feng, Cheng L, Li Y, Qian J, Ding, Gao F, Xia Guohua, Chen N, Lu z. Janus kinase -2 (JAK2) A830G polymorphism and its relationship with the treatment outcome of patients with acute myeloid leukemia. Leucker lymphoma. 20 10; 5 1(6): 1 1 15-20.
37. Nina, Zhang, yan lin, Chen Ping, Min Jian, Wang Zhi, Xiao and Chen Ba. Relationship between the mechanism of apoptosis induced by gambogic acid and transferrin receptor in non-small cell lung cancer cells. J Chemother。 2009; 2 1(6):666-72.
Pei Xiaoping, Chen Ba *, Li Li, Gao Fang, Jiang Ze. Application of novel chemiluminescence immunoassay based on colloidal silica crystal microspheres in the detection of tumor markers. Analyst. 20 10; 135( 1): 177-8 1.
39. Chen Ba *, Liang Yongqiang, Wu Weihua, Cheng Jun, Xia Guohui, Gao F, Ding, Gao C, Shao Z, Li G, Chen W, Xu, Sun Xiaochun, Liu Lijun, Li Xiaomei and Wang Xiaomei. Synergistic effect of magnetic nanoparticles ofe(3)O(4) and gambogic acid on apoptosis of K562 leukemia cells. International Journal of Nanomedicine 2009; 4:25 1-9.
40. Cheng Jie, Wu WW, Chen Ba *, Gao F, Xu, Gao C, Ding, Sun, Song HH, Bao W, Sun, Xu C, Chen W, Chen N, Liu Lijun, Xia GH, Li Xiaomei and Wang Xiaomei. Reversal effect of Fe3O4 and 5- bromotetrandrine magnetic nanoparticles on multidrug resistance of K562/A02 leukemia cells. International journal of nanomedicine. 2009; 4:209- 16.
4 1. Pei Xiaoping, Zhao Y, Zhao X, Xu H, Chen Ba *, Gu ZZ. Multiple chemiluminescence immunoassay based on colloidal crystal beads of silica gel. Japan Proclamation 2009; 9( 1 1):6320-5.
42. Sun N, Sun, Chen Ba *, Cheng H, Feng, Cheng L, Lu. Polymorphism of MRP2 and GSTP 1 and chemotherapy response of advanced non-small cell lung cancer. Cancer chemistry and pharmacy. 20 10; 65(3):437-46.
43. Li Y, Deng Z, Xuan H, Zhu J, Ding B, Liu X, Chen Ba *. The chronic phase of chronic myeloid leukemia was prolonged after homoharringtonine treatment. China Journal of Medicine (English). 2009; 122( 12): 14 13-7.
44. Jiang Z, Chen Ba *, Xia Gang, Wu Q, Zhang Y, Hong T, Zhang W, Cheng J, Gao F, Liu Lijun, Li Xiaomei, Wang Xiaomei. Reversal effect of magnetic Fe3O4 nanoparticles loaded with cisplatin on ovarian cancer cells. International journal of nanomedicine. 2009; 4: 107- 14.
45. Chen Ba *, Cheng J, Wu Yun, Gao F, Xu, Shen Honglin, Ding, Gao C, Sun Q, Sun, Cheng H, Li G, Chen N, Liu Lijun, Li Xiaomei and Wang Xiaomei. Reversal of multidrug resistance of transplanted tumor in nude mice by magnetic Fe3O4 nanoparticles copolymerized with daunorubicin and 5- bromotetrandrine. International journal of nanomedicine. 2009; 4:73-8.
46. Chen Ba *, Cheng J, Shen Mingfeng, Gao F, Xu, Shen Honglin, Ding, Gao C, Sun Q, Sun, Cheng H, Li G, Chen W, Chen N, Liu Lijun, Li Xiaomei and Wang Xiaomei. Synergistic effect of Fe3O4 magnetic nanoparticles and 5- bromotetrandrine induced daunorubicin-induced leukemia cell apoptosis. International journal of nanomedicine. 2009; 4:65-7 1.
47. Chen Ba *, Dai, Wang Xiaomei, Zhang R, Xu, Shen Hailin, Gao F, Sun Q, Deng X, Ding, Gao C, Sun Y, Cheng J, Wang J, Zhao G, Chen N. Synergistic effect of nanoparticles Fe3O4 and Au with daunorubicin on K562/A02 cells. International journal of nanomedicine. 2008; 3(3):343-50.
48. Chen Ba *, Sun Q, Wang Xiaomei, Gao F, Dai, Yin Y, Ding, Gao C, Cheng J, Li, Sun, Chen N, Xu, Shen Hailin, Liu D. Fe3O4 magnetic nanoparticles loaded with adriamycin and tetrandrine reverse multidrug resistance of K562/A02 leukemia cells. International journal of nanomedicine. 2008; 3(2):277-86.