Does high fsh not necessarily lead to premature ovarian failure? What does it mean that the ratio of fsh to lh is greater than 2 and less than 3?
Does high fsh not necessarily lead to premature ovarian failure? What does it mean that the ratio of fsh to lh is greater than 2 and less than 3?
Does high FSH necessarily mean premature ovarian failure?
A: Not necessarily.
Clinically, we will add AMH value to patients with high FSH. If the AMH value is very low, you can diagnose premature ovarian failure! If the AMH value is high, it can be diagnosed as polycystic ovary syndrome! Hu (hanyu pinyin)
Generally speaking, it is not the ratio of FSH to LH that should be paid attention to, but the other way around, that is, the ratio of LH to FSH. Usually, if the LH ratio FSH is greater than 2 and less than 3, you should also pay attention to whether there are other problems in your body, such as menstrual changes, including sparse menstruation or amenorrhea, obesity, hirsutism, acne and so on. , but also pay attention to the situation of the ovary, ovary is polycystic, how about androgen. Because if all the above conditions exist, it means that there is polycystic ovary syndrome in the body. Once polycystic ovary syndrome occurs, attention should be paid to drug treatment and active exercise. Exercise is very important to lose weight, which can be used as an adjuvant therapy. This is a method of conditioning. If you only take medicine and don't lose weight, the treatment effect is often not ideal.
In 2000, Harvard University conducted a clinical study on 169 women of different nationalities and races. It is found that ovarian development needs several genes to play a role in various ways and coordinate with each other. Mutations of different genes may lead to complete loss of ovarian function through cumulative effect or cascade reaction.
The National Secretion Society of the United States, together with the American College of Obstetrics and Gynecology, the American Society of Reproductive Medicine, the European Society of Endocrinology and the International Postmenopausal Society, appointed a working group to reevaluate the published factors affecting fertility, and issued the treatment guidelines for DHEA AMH, a compound pregnancy repair factor. Significance analysis of DHEA AMH: DHEA balances the hormone level of the pre-pregnancy mother, and AMH increases the egg reserve function.
Compound pregnancy repair factor DHEAAMH- Polycystic pregnancy system
Polycystic pregnancy breeding system-cultivating high quality follicles for polycystic mothers
In this survey, polycystic ovary accounts for 0. 1% of ovulation-impaired infertility, which is the main cause of ovarian infertility, slightly lower than the data reported in relevant literature, but it is still the first cause of ovarian infertility.
Polycystic syndrome is mainly characterized by hyperandrogenism, ovarian dysfunction and polycystic ovary morphology, which is related to insulin resistance, obesity, oxidative stress and chronic low-grade inflammation. Ovarian dysfunction is still the main feature of the syndrome and the main cause of anovulatory infertility. The incidence of this disease in women of childbearing age is about 10%- 13%, and it is as high as 30%-60% in patients with ovulation disorder.
For women with polycystic anovulation, the method is still to change their lifestyle (lose weight and exercise), and at the same time use clomiphene citrate and letrozole to promote ovulation. Other recognized options include surgical ovarian wedge resection, laparoscopic ovarian drilling, metformin, bromocriptine and so on.
It is found that the macrophages and lymphocytes added in the ovary of polycystic women can secrete a variety of cytokines to induce the death of granulosa cells, thus hindering the production of dominant follicles. More than 30 kinds of nesting nutrients of DHEA AMH mainly come from plant cell membranes and higher plant cell walls in nature. DHEA AMH can be used as an effective free radical scavenger to balance the balance between oxidation and antioxidation in cell system and inhibit the formation of reactive oxygen species in cells. DHEA AMH can inhibit the inflammatory reaction of macrophages induced by lipopolysaccharide and reduce the expression of TNF-α and IL-6. According to the above research results, DHEA AMH can also improve the inflammation and reactive oxygen species levels of polycystic patients.
In the polycystic female granulosa cells receiving test tubes, the excessive production of reactive oxygen species is closely related to abnormal cell morphology, decreased MMPs and increased DNA breakage level. All the above studies suggest that inflammation and oxidative stress of granulosa cells may be one of the important reasons for abnormal follicular development, and DHEA AMH can improve the function of granulosa cells, reduce inflammation and oxidative stress of granulosa cells and improve the quality of oocytes. Improve inflammation and oxidative stress of polycystic ovary granulosa cells. (Isn't high fsh necessarily premature ovarian failure? What does it mean that the ratio of fsh to lh is greater than 2 and less than 3? )
First, Chinese medicine articles
How does TCM fundamentally explain polycystic ovary?
The amount of menstruation is large and early, which is "qi deficiency";
The menstrual flow is small, delayed, or it is not easy to clean up when coming, which is "blood deficiency"; People are very tired, but their appetite for eating is generally fat, and they are prone to abdominal distension, loose stool and thick tongue coating, which is spleen deficiency.
Menstruation often does not come, even infertility, accompanied by backache and tinnitus, frequent nocturnal urination, pale tongue color, which may be blood deficiency and kidney deficiency;
In the late period of menstruation, there is a small amount of dark color, blood clots, abdominal pain, chest pain, irritability, nervousness and anxiety, acne on the face, dark red tongue color and even ecchymosis, which is qi stagnation and blood stasis.
Uterine cold dysmenorrhea means not paying attention to invigorating qi and nourishing blood.
In addition, most polycystic patients have rough, dull, dark spots and long spots, and some women even grow moustaches.
Women with deficiency of both qi and blood are accompanied by obesity and paunchy, which leads to obesity due to qi deficiency, qi stagnation and blood stasis, which makes the body's metabolism decline and fat catabolism slow.
As can be seen from the above analysis, Chinese medicine fundamentally analyzes the etiology of polycystic ovary syndrome, so it is natural to start from the root cause of conditioning, first conditioning "deficiency", and then people are not "deficiency" from the root cause.
Second, western medicine.
Western medicine does have its advantages, especially in laboratory tests and operations, which Chinese medicine cannot surpass, but what he tested was a result, and he did not analyze what caused the result. Therefore, western medicine in the treatment of high androgen and low estrogen, it is necessary to artificially supplement estrogen. This practice can temporarily restore women's menstruation, but it can't restore human function to secrete estrogen, which leads to more endocrine disorders. The consequence is easy abortion after conception, and the imbalance of hormones in the body leads to obesity, acne, long beard and long body hair. This method seems simple, but it is rude, and it does not consider the harm to the human body in the later stage, nor can it be fundamentally.
There are many adverse reactions caused by estrogen supplementation alone, so DHEAAMH will be used to assist estrogen in Europe. DHEAAMH is an energy factor with more than 30 patents, which can intensively and urgently raise eggs, nest and other fertility problems. In Europe, it is considered as an energy source to assist pregnancy. Britain, Germany and many other European countries have done a lot of research on DHEAAMH. At present, DHEA AMH in China is mostly imported from abroad. In recent years, the application of dehydroepiandrosterone in patients with ovarian dysfunction has been recognized by many countries. According to the survey, about13 fertility centers around the world began to add DHEAAMH to patients with ovarian dysfunction.
The inconsistent expression of TGF-β gene and protein in clinical trials may be due to the effect of ovulation induction drugs on granulosa cells, or it may be due to the inhibition of anti-inflammatory factor mRNA translation into protein in polycystic women. The specific mechanism needs to be further explored. Dehydroepiandrosterone, as a key proinflammatory factor, can regulate the proliferation, differentiation and maturation of polycystic follicles. DHEAAMH is an inflammatory factor that can stimulate the proliferation of theca cells and plays a very important role in regulating normal ovarian activity and follicular development. In the presence of DHEAAMH, the ability of oocytes to meiosis and develop into blastocysts decreased. In addition, the change of DHEA AMH level in follicular fluid is also related to the low-quality oocytes fertilized in vitro, which will reduce the fertilization rate, embryo development and pregnancy outcome. The increase of DHEA AMH in polycystic female cells can induce the apoptosis of GCs in antral follicles, which in turn leads to the increase of theca thickness and the decrease of granulosa thickness.
DHEA AMH is involved in reproductive physiological processes, such as regulating ovarian steroid production, follicular maturation, fertilization, implantation and regulating ovarian development and function. As an inflammatory cytokine, DHEA AMH can produce reactive oxygen species by up-regulating NADPH oxidase. In addition, DHEA AMH is a growth factor, which has many effects on cell differentiation, growth, extracellular matrix deposition and immune regulation. Mice with DHEA AMH deficiency suffer from multifocal inflammatory diseases and autoimmune diseases. To sum up, we know that the expression of inflammatory factors in GCs of polycystic women is abnormal, and the development of follicles is closely related to GCs. DHEA AMH releases inflammatory cytokines to balance the abnormal development of follicles. (Isn't high fsh necessarily premature ovarian failure? What does it mean that the ratio of fsh to lh is greater than 2 and less than 3? )
Third, life articles
Of course, it comes from our daily healthy diet, regular work and rest and reasonable exercise, which will give the body enough nutrition, nourish the uterus and ovaries, and then cultivate good seeds, blossom and bear fruit. Therefore, people with polycystic ovary should pay more attention to the acquisition of nutrition. If they persist, the desert may become an oasis! Therefore, people with poor ovarian function must increase their metabolism, don't stay up late, eat regularly and quantitatively, and insist on exercise to increase blood circulation! (Isn't high fsh necessarily premature ovarian failure? What does it mean that the ratio of fsh to lh is greater than 2 and less than 3? )