1, tissue fixation technique
This technology completely cancels the traditional glutaraldehyde cross-linking fixation process, and uses specific epoxide to cross-link and fix it under specific conditions, thus solving the problem of residual toxicity of glutaraldehyde fixation process, and greatly improving the stability of animal tissues, making it a new material that can be passively and flexibly degraded with tissue regeneration, and its degradability can be regulated through process design. This technology has been patented in China, the United States, Britain, France, Germany and Australia, and Japanese, Russian and Canadian patents are applying for PCT.
2. Multi-directional antigen removal technology
According to the principles of molecular immunology and immunochemistry, the method of blocking the specific active groups causing antigen reaction and changing the specific conformation is designed, which can effectively remove the antigenicity of heterogeneous tissues and improve the histocompatibility, which is beneficial to the growth, division and proliferation of cells in them.
3. protein mechanical modification technology.
Based on the principle of molecular design, collagen, the main component of the material, was crosslinked and grafted to improve its mechanical properties. On the one hand, the product can obtain better biomechanical compliance, on the other hand, it can toughen and strengthen the material through mechanical modification, making up for the loss of mechanical properties caused by biochemical treatment and sterilization, which makes the biochemical treatment and virus killing methods more free. More harsh biochemical treatment conditions can effectively remove immune rejection, and conventional sterilization methods can kill possible animal viruses, making the virus killing more thorough.
4. Tissue induction technology
By introducing specific peptides or other active substances that can adhere to growth factors and cells on the surface of materials or products, the products are endowed with the function of recruiting growth factors and stem cells, inducing stem cells to differentiate into cells related to regenerative tissues, and further dividing and proliferating. These growth factors and stem cells are released and transported to the wound site through the body's self-repair mechanism after the product is implanted. They are enriched on the surface of products through the adhesion of specific peptides or other active substances and expressed efficiently, which constitutes the basis of in-situ induced regeneration.