In the past 10 years, he has been mainly engaged in research on the gene structure and function of Plasmodium falciparum, Schistosoma japonicum and liver fluke and molecular vaccine research. In recent years, he has carried out research on helminth stem cells and has won national and provincial awards such as the National Natural Science Foundation of China. There are more than 30 ministerial-level science funds, with a total fund amount of nearly 6 million yuan.
The projects undertaken include:
⒈ Research on the anti-asthma molecular effect mechanism of parasite TCTP (30571634), National Natural Science Foundation of China 250,000, 2006-2008;
⒉ Discovery and functional study of Schistosoma japonicum signal transduction-related molecules, National Natural Science Foundation of China 250,000, 2006-2008;
⒊ Development of probiotic fish vaccine to prevent liver fluke disease;
⒋ Research on the functional genome and proteomics of liver flukes (2004A30801004), Guangdong Provincial Key Science and Technology Project RMB 300,000, 2004-2006;
⒌ Development of liver fluke disease census and diagnostic kits, Guangzhou Science and Technology Plan Key Project 400,000, 2006-2008;
⒍ Research and development of a universal non-invasive Clonorchis sinensis rapid diagnostic kit (2004B36001027), Guangdong Province Science and Technology Plan Project 100,000, 2004 -2006. He has published more than 200 academic papers, including 13 SCI papers, and edited and published "Modern Applied Molecular Parasitology".
⒈ Lu G, Hu X, Peng Z, Xie H, Li Y, Wu Z, Yu X. Expression and characterization of lactate dehydrogenase from Schistosoma japonicum. Parasitol Res. 2006 May 11
< p>⒉ Lu J, Guo Z, Pan X, Wang G, Zhang D, Li Y, Tan B, Ouyang L, Yu X .Passive immunotherapy for influenza A H5N1 virus infection with equine hyperimmune globulin F(ab')2 in mice .Respir Res. 2006 Mar 23;7:43⒊ Zheng N, Huang B, Xu J, Huang S, Chen J, Hu X, Ying K, Yu X. Enzymatic and physico-chemical characteristics of recombinant cMDH and mMDH of Clonorchis sinensis. Parasitol Res. 2006 Jul;99⑵：174-180
⒋ Yang G,Jing C,Zhu P,Hu X,Xu J,Wu Z,Yu X. Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis. Parasitol Res. 2006 Jun;99⑴：55-64
⒌ Wu Z,Wu D,Hu X,Xu J,Chen S,Wu Z,Yu X. Molecular cloning and characterization of cDNA encoding a novel cytosolic glutathione transferase from Clonorchis sinensis. Parasitol Res. 2006 May;98⑹：534-8
⒍ Znancai Zheng,Jin Xu,ZhongdaoWu,Yu X et al. Clonorchis sinensis: molecular cloningand functional expression of a novel cytosolic malate dehydrogenase.
Experimental Parasitology, 2005,109:220-227
⒎ Guang Yang, Xinbing Yu, Zhongdao Wu, et al. Molecular cloning and characterization of a novel adenylate kinase 3 gene from Clonorchis sinensis. Parasitol Res, 2005,95:406-412
⒏ Peng Zhaiyu, Yu Xinbing, Wu Zhongdao, et al. Cloning and expression in Escherichia coli of a new gene of Schistosoma japonicum encoding casein kinase Ⅱ beta subunit. Chin Med J 2004,117⑼：1321-1325
⒐ Linxia Song,Shouyi Chen. Xinbing Yu,Zhongdao Wu,et al. Molecular cloning and characterization of cDNA encoding a ubiquitin-conjugating enzyme from Clonorchis sinensis. Parasitol Res 2004, 94:227-232
⒑ Wu Z, Liu S, Zhang S, Tong H, Gao Z, Liu Y, Lin D, Liu Z, Wu G, Yi H, Song G, Xu Y. Persistence of the protective immunity to Schistosoma japonicum in Chinese yellow cattle induced by recombinant 26kDa glutathione-S-transferase (reSjc26GST). Vet Parasitol. 2004 Sep 2;123(3-4):167-77.
⒒ Z.Wu, Xinbing and WU Zhongdao.Generation and analysis of 113 adult stage Schistosoma japonicum (Chinese strain) expressed sequence tags. Chinese Medical Journal (English version of Chinese Medical Journal) 2002.10; 115⑽: 1517-1520
⒔ Compiled by Yu Xinbing "English-Chinese Dictionary of Biochemistry and Molecular Medicine", China Medical Science and Technology Press, 2004.01
⒕ Deputy editor-in-chief Yu Xinbing "Molecular Parasitology", Shanghai Science and Technology Press 2004
5. Achievements
It has won 6 provincial and ministerial science and technology progress awards and natural science awards, and 2 utility model patents.
⒈ Yu Xinbing (the second person to complete the project), experimental research on multivalent composite gene vaccine against Plasmodium falciparum antigen, third prize of Guangdong Province Science and Technology Progress Award in 2001.
⒉ Yu Xinbing (the 3rd completer), Comprehensive research on the cultivation of human Echinococcus granulosus cell lines and immunological prevention of hydatid disease. 2001 Second Prize of Science and Technology Progress Award of Xinjiang Uygur Autonomous Region.
⒊ Yu Xinbing (first author), research on antigen gene structure and immunogenicity of Plasmodium falciparum (Hainan strain), second prize of Guangdong Province Science and Technology Progress Award in 2003.
⒋ Patent - Clonorchis sinensis metacercariae immune colloidal gold detection kit, patent number: ZL 03 2 24470.3, application date: 2003.03.24, authorization announcement date: 2004.02.25
⒌ Patent - Clonorchis sinensis metacercariae immune colloidal gold detection kit, patent number: ZL 03 2 24469. The laboratory and the Molecular Protozoa Research Laboratory of the Teaching and Research Section of Parasitology carry out research work. Research directions include: ① vaccine research on infectious diseases, the current research focus is on vaccine research on schistosomiasis japonicum and vaccine research on respiratory infectious diseases; ② molecular diagnostic technology, the research focus is on molecular diagnostic technology on parasitic diseases and bacterial infections . The team currently has 3 professors, 1 associate professor, 2 lecturers and postdoctoral fellows, and 10 master's and doctoral candidates. The established technology platforms include: ① identification, cloning and bioinformatics technology analysis of new genes; ② recombinant expression, purification, immunology and biological identification technology of protein genes; ③ two-dimensional electrophoresis and mass spectrometry analysis of proteins, etc.; ④ tree Isolation, identification and related immunological techniques of dendritic cells (DC).