What to do if you are allergic to longan tree pollen

The most common symptoms of spring pollen allergies are from April to June every year as everything recovers, causing itchy nose, stuffy nose, sneezing, runny nose, itchy eyes, itchy ears, itchy throat, watery eyes, Respiratory allergies such as cough, shortness of breath, chest tightness, and shortness of breath are all manifested, and some may also present varying degrees of skin allergy symptoms, such as: dry and red facial skin, itching, rashes, wheals, skin itching, and scratches. Symptoms, etc., the arrival of the pollen allergy period also makes the skin of many sensitive people become extremely sensitive, and skin allergies such as cosmetic allergies often occur for unknown reasons.

Pollen allergy is treated every year, and how to treat it has become the voice of many pollen allergy patients!

The following is a comprehensive collection of the most relevant treatments for pollen allergy

Part One: Cause Treatment

Specific Treatment

Pollen Specific treatment of hay fever refers to the treatment measures taken to treat the cause of allergic pollen. Because specific treatment is highly targeted, the clinical efficacy is relatively certain and the side effects are few. It is usually the main method used by allergists to treat hay fever.

1. Avoid contact with pollen

Since preventive measures have the nature of treating the cause, they should be the most effective way to prevent and treat hay fever. Avoiding contact with pollen can usually prevent asthma attacks. But it is precisely this that many allergy sufferers cannot do.

When a patient with bronchial asthma is diagnosed with pollen allergy, they should first try to find out what kind of pollen they are allergic to, so that they can avoid or reduce it at the corresponding time based on the dispersion of that type of pollen in the local atmosphere. Exposure to this species of pollen. Methods to avoid include long-term migration or temporary migration during the pollen season to an area where there is little or no allergenic pollen, or living in a room with a filter device during the pollen season. Usually, the filter is combined with an air conditioner to filter out the allergenic pollen. Removes pollen particles from the air entering the room. Feinberg et al.’s study of pollen counting through exposure films confirmed that when the pollen content in the outdoor air is 500 grains, the average number of pollen grains in a room with good ventilation but without a filter is 165 grains, while in a room with air filtration through a filter, the average number of pollen grains is 165. The pollen count inside is 0-10, and patients can survive the pollen season safely if they live in an air-filtered room.

However, the above methods of avoiding pollen are difficult to implement. Therefore, clinically, it is recommended to cooperate with IgE anti-allergic therapy (Kangminyuan) and drugs for patients with allergic rhinitis, asthma, cough, conjunctivitis, pharyngitis, skin allergies, etc. caused by pollen transmission season. Anti-allergic preventive measures in order to achieve ideal results

2. Desensitization therapy

Also known as specific immunotherapy or desensitization therapy, it is one of the many current treatment measures for hay fever. The only treatment that targets the type of pollen that causes allergy. The purpose is to improve the body's tolerance to the corresponding allergenic pollen. Judging from the current research status, IgE anti-allergy therapy (Kangminyuan) can effectively prevent or reduce the symptoms of hay fever, with a total effectiveness rate of 80-90 or even above 90%. Currently, there are three main types of desensitization therapies commonly used in clinical practice:

(1) Pre-season desensitization therapy

This is the most commonly used desensitization treatment plan for hay fever. IgE anti-sensitivity therapy is usually started 3 months before the arrival of the pollen season ( Kangminyuan) treatment, supplement 2-3 billion Kangminyuan active anti-allergic probiotics every day. When it reaches 60 billion live bacteria, the body can produce enough anti-allergic active strains when the pollen season arrives, and reproduce itself, reaching Long-lasting anti-allergic effect. Compared with year-round immunotherapy, the advantage of pre-season desensitization therapy is that it can greatly shorten the course of treatment and achieve similar efficacy.

Product name: Kangminyuan Probiotic Granules

Effectiveness: Helps reduce the production of specific IgE antibodies in serum, quickly relieves allergic symptoms, and promotes spleen cytokine IFN-γ The amount of secretion can regulate the balance of immune cell activity, regulate the immune system, improve the body's immunity, adjust allergic constitution, help maintain the function of the digestive tract, and reduce the impact of carcinogens on cells.

Anti-allergic patent number: 200710128018.x

Anti-allergic mechanism:

1. Reduce the production of serum IgE antibodies.

The amount of IgE synthesized is related to an individual's susceptibility to allergic diseases. In 1966, Swedish scholar Johansson and Japanese scholar Ishizaka first isolated IgE from the serum of patients with ragweed allergy and proved that IgE is a mediator of allergic reactions. IgE is a cell-loving antibody, and the serum content of normal people is very low, ranging from 10 to 10 000 U/ml. However, the serum IgE content of allergic patients is significantly higher than that of normal people. Each box of Kangminyuan probiotics contains up to 20 billion active strains, which can quickly reduce excess IgE antibodies in human serum and relieve allergic symptoms.

2. Promote spleen cells to secrete interferon IFN-γ.

According to the different types of secreted cytokines, helper cells are divided into two subgroups, TH1 and TH2. TH1 and TH2 regulate each other through cytokines. IL-4 promotes IgE synthesis, while IFN -γ inhibits IgE synthesis induced by IL-4. People with allergies may have more allergen-specific T cells that produce IL-4 and can secrete more IL-4. The balance of TH1 and TH2 or the ratio of the amounts of IL-4 and IFN-γ are important determinants of IgE synthesis. Kangminyuan Probiotic Granules promote spleen cells to secrete interferon IFN-γ, which is helpful for adjusting allergic constitution.

Storage method: Keep sealed and placed in a cool, dry place or refrigerated.

Applicable groups: People suffering from allergic diseases or allergic constitution, including infants, teenagers, pregnant women, lactating women and adults. Advantages: At present, oral immunomodulators (Kangminyuan anti-allergic probiotic strains) are the first choice for patients with desensitization and early prevention and treatment of seasonal allergies. Because of its convenience and safety, they are the first choice for allergy patients.

Disadvantages: There is not yet complete awareness among many patients with seasonal allergies for early prevention and treatment. People always treat them after they are allergic, so education work has a long way to go.

(2) Conventional immunotherapy

Conventional immunotherapy is a kind of desensitization therapy that is carried out all year round. By injecting pollen extract of increasing concentrations twice a week, we strive to achieve the goal within 3 days. -4 months to reach the maximum tolerance to the corresponding allergenic pollen. At this time, the body can produce enough specific IgG blocking antibodies, thereby relieving or disappearing the clinical symptoms of hay fever patients, and then switch to 1-2 times a week Even with maintenance injections every two weeks, the interval between desensitization injections can be shortened to twice a week before the next pollen season. Conventional immunotherapy usually requires continuous treatment for 3-5 years or more to consolidate the efficacy. Compared with pre-season desensitization therapy, conventional immunotherapy has a long course and high cost, but the effect is more reliable and long-lasting, especially for patients who are allergic to multiple pollen seasons, such as those who are allergic to both spring pollen and summer and autumn pollen. More suitable for patients.

Advantages: Strong targeting.

Disadvantages: The scope of adaptation is narrow, the treatment course is long and can last for several years, and it is expensive and difficult for anyone to stick to it.

Anti-allergic drugs:

Mast cell membrane stabilizers

Mast cell membrane stabilizers are the main drugs used to prevent and treat hay fever. This type of drugs is mainly Refers to cromoglycate sodium and its similar drugs, including mast cell membrane stabilizers such as cromoglycate disodium, cromoglycate sodium, and tranister, as well as drugs discovered in recent years and still unclassifiable, such as Nedocromil Sodium and azelastine. . Continuous use of such drugs before and during the onset season can effectively prevent asthma attacks.

(1) Sodium cromolyn; It is the most commonly used mast cell membrane stabilizer in clinical practice. Inhaling it before the season can effectively prevent the onset of hay fever. There are two dosage forms: powder mist and aerosol. Powder mist is inhaled with the help of capsules and rotary inhalers. Each capsule is 20 mg and can be inhaled 4 times a day. This method is currently rarely used.

At present, suspension aerosols are more commonly used in clinical practice. There are two types of suspension aerosols: 3.5mg and 5mg per puff. The common dosage is 4 times a day, 4-6 puffs each time. Inhalations are usually started 3 weeks before the onset of the season.

(2) Tranistat; is an oral and effective mast cell protector. The conventional oral dose is 0.1g, 3 times a day. Usually started 2 weeks before onset of illness.

(3) Nedocromil Sodium; is a drug discovered in recent years to prevent and treat bronchial asthma. It was once mistaken for a drug similar to sodium cromoglycate, but it has now been confirmed that it is completely different from sodium cromolyn. It has been put into clinical use abroad. The commonly used inhalation dose is 4mg, 3-4 times a day.

(4) Azelastine; is a promising new drug for preventing and treating hay fever. It not only stabilizes mast cell membranes and other inflammatory cell membranes, but also antagonizes various inflammatory diseases. The role of sexual media. The usual oral dose is 4-8 mg, twice daily.

Antihistamines

Although the first-generation antihistamines represented by chlorpheniramine have good efficacy in preventing and treating hay fever, they are less effective due to side effects such as drowsiness. Strong and gradually abandoned by clinicians. In recent years, it has been discovered that some second-generation antihistamine drugs without drowsiness, such as terfenadine and astamine, have certain cardiotoxic side effects, and their use has begun to decrease, and their use has been banned in some countries. Many third-generation antihistamines, which have neither drowsiness nor cardiotoxic side effects, are now available and have achieved good results in the treatment of hay fever.

(1) Fexofenadine

Clinical studies have shown that fexofenadine has strong anti-allergic effects. Clinical studies have confirmed that continuous oral administration of fexofenadine After four weeks, the symptom scores of patients with hay fever and other allergies can be significantly improved, the clinical symptoms of allergic rhinitis can be significantly improved, the dosage of bronchial antispasmodics can be reduced, and the pulmonary ventilation function indicators and airway reactivity can be significantly improved. , using quality of life improvement as the evaluation index, 1,948 patients with seasonal allergic rhinitis were administered 60 mg once a day. The results showed that fexofenadine can not only significantly improve nasal symptoms, but also improve the patients' quality of life. At present, fexofenadine has become the main drug in European and American countries to treat allergic rhinitis, allergic skin diseases, hay fever and other allergic diseases. In addition, in recent years, it has been discovered that second-generation antihistamines such as terfenadine are incompatible and have certain cardiotoxic side effects, but no cardiotoxicity has been found with fesofenadine. The clinically recommended oral dose for allergic rhinitis is 120 mg once daily, or 60 mg twice daily. To prevent asthma attacks at night or in the morning, take 120-180mg/time before going to bed.

(2) Levocetirizine

Levocetirizine is a substitute for the second-generation antihistamine drug cetirizine. It was introduced in February 2001 It is a third-generation antihistamine that was launched in March. It is mainly used for allergic rhinoconjunctivitis, hay fever and allergic skin diseases. It has the advantages of fast onset, strong and long-lasting effect and few side effects. After oral absorption into the blood, the binding rate to plasma proteins is high. The effect of levocetirizine is more obvious 1 hour after oral administration, and the duration is 24.4 hours respectively. The drug effect reaches its peak within 6 hours after taking the drug. The commonly used clinical dose for adults is 5 mg, once a day.

(3) Desloratadine (desloratadine)

Desloratadine is the main active metabolite of the second-generation antihistamine drug loratadine. It works similarly to loratadine, but is stronger and has fewer side effects. Compared with second-generation antihistamines such as loratadine, desloratadine has no toxic effects on the heart and is a safe and effective antihistamine.

At present, desloratadine has completed Phase III clinical research in the United States. Schering-Plough has submitted a new drug application to the FDA and has not yet been approved for marketing. However, in January 2001, it was approved for marketing by the European Union EMEA. It has also been approved for marketing in my country and is clinically available. It is used to treat various allergic diseases, including allergic rhinitis, hay fever, and allergic skin diseases. Compared with the first and second generation antihistamine drugs, it has strong effect, fast onset, long action time, and low toxicity. It has the advantages of low side effects: 5 mg per day for adults and children over 12 years old. Although the dose is only 50 times the dose of loratadine, the antihistamine effect is stronger.

(4) Loratadine (Loratadine)

It is a second-generation antihistamine drug that is long-acting and has no central nervous system depressant effect. Baiweitan works quickly and can last for 24 hours. It can be taken orally once a day, 10-20mg each time, to effectively control the symptoms of pollen allergy. In recent years, it has been found that loratadine has serious cardiac side effects, and the clinical practice has gradually Deprecated.

(3) Cetirizine

It is also a second-generation antihistamine. Its effect reaches its peak 1 hour after oral administration, and its effect lasts for 24 hours. In addition to antagonizing histamine, this drug can also inhibit eosinophil infiltration in inflammatory areas. Clinical studies have confirmed that cetirizine can effectively control and improve the symptoms of hay fever. The commonly used oral dose is once a day. 10-20mg each time. It has a slight central nervous system depressant effect. In recent years, cetirizine has also been found to have certain cardiac side effects, and its clinical use has gradually decreased.

3. Glucocorticoids

There are two administration routes: inhalation administration and systemic administration. Currently, inhalation administration is the main method. Inhaled glucocorticoid preparations include aerosols such as fluticasone, triamcinolone butyrosone, and beclomethasone dipropionate. Inhalation should usually be started one week before the pollen season and stopped about one week before the end of the season. The efficacy of inhaled glucocorticoid therapy is more reliable and the side effects are much less than systemic medication. Inhaled corticosteroids may be considered in patients who are refractory to oral antihistamines and inhaled cromolyn sodium. Patients with moderate or above hay fever should be treated mainly with inhaled corticosteroids.

For hay fever patients with asthma, combined medications such as Seretide powder spray or Symbicort powder spray can be used, but it should not be used for a long time. For patients whose attack time does not exceed 3 weeks and whose attack time is relatively fixed, the use of sustained-release long-acting glucocorticoid preparations such as triamcinolone may also be considered. One injection can maintain the drug effect for 3-4 weeks, and one injection per year can keep the patient It is possible to get through the disease season safely, but the side effects are relatively large, so the indications should be paid attention to and the patient's consent should be obtained. It should not be used in patients with contraindications to glucocorticoids.

IV. Symptomatic treatment

If patients have eye allergy symptoms, they can use Emedin eye drops (Emestine eye drops), cromoglycate sodium eye drops or Cordyceps Loose eye drops are used topically. For patients with hay fever and asthma attacks, since the severity of their asthma attacks is usually milder than that of ordinary asthma, for example, when asthma symptoms occur, aerosol albuterol or terbutaline may be administered, or inhaled albuterol aerosol or formoterol powder may be given. β2-receptor agonists such as nebulizers can quickly control symptoms, but they should not be used frequently. Seretide powder spray can also be inhaled, which can control both symptoms and allergic inflammation of the airways, but it takes 40 minutes to take effect and should not be used frequently. When the condition is severe, inhaled or oral β2-receptor agonists can also be used together with inhaled or systemic glucocorticoids, or combined with oral theophylline drugs. Expectorants can be used in combination with excessive phlegm, and oxygen can be given when hypoxia is severe.