The exact cause of Alzheimer's disease has not been determined. The following reasons can induce Alzheimer's disease: 1. Genetic factors: A few patients have family history and gene mutation, which leads to abnormal accumulation of neuron protein, thus leading to neuron degeneration and death. 2. Non-genetic factors: often related to dyslipidemia, hyperglycemia, hyperhomocysteinemia, oxidative stress, mitochondrial dysfunction, toxic effects of excitatory amino acids, etc. , leading to neuronal degeneration and death, thus causing cognitive dysfunction in patients.
Previously, the research of the relevant research group of Shanghai Institute of Pharmacology, China Academy of Sciences further confirmed that the disorder of intestinal flora itself was enough to cause neuroinflammation in the brain during the onset of AD, and it was found for the first time that the abnormal increase of amino acid metabolites from flora was an important mechanism of neuroinflammation induced by flora and the key to cognitive impairment of AD. More importantly, the team revealed for the first time that GV-97 1 can improve cognitive function by reshaping the balance of intestinal flora, reducing the production of intestinal flora metabolites, especially phenylalanine and isoleucine, reducing peripheral and central inflammation, and reducing Aβ deposition and Tau hyperphosphorylation in the brain.