In March 1994, he obtained a doctorate in pharmacy from the Department of Pharmacy, Tohoku University, majoring in pharmaceutical physical chemistry. Currently, he is a distinguished professor and doctoral supervisor at Nankai University.
Personal study and work experience:
1980.09-1984.07 Bachelor of Science in Physical Chemistry, Department of Chemistry, Nankai University; 1988.04-1994.03 Pharmacy, Tohoku University, Japan majored in physical chemistry of pharmaceuticals, and obtained a master's degree in pharmacy and a doctorate in pharmacy;
1996.03-2001.04 Taught at the Graduate School of Pharmacy, Tohoku University, Japan and completed on-the-job postdoctoral research, becoming the first foreign teacher since the establishment of the Department of Pharmacy at Tohoku University;
2001.05- Now teaches at the School of Life Sciences of Nankai University and established the biosensor laboratory. He concurrently serves as deputy director of the Key Laboratory of Bioactive Materials of the Ministry of Education. He has established the field of new diagnostic materials, developed new analytical techniques for molecular interactions and molecular recognition, constructed new methods for research on the mechanism of action of traditional Chinese medicine and the compatibility rules of prescriptions, functional microorganisms and their Interdisciplinary research in environmental protection, agricultural applications and other fields.
Current main research directions:
Bioelectroanalytical chemistry, biomedical sensing technology, traditional Chinese medicine pharmacology and drug analysis
Research results:
Achievements have been made in new nanomaterial photoelectrochemical technology, high-performance nanostructured immobilized enzyme electrode preparation technology, new analytical technology for intermolecular interactions and molecular recognition, and the construction of new methods for studying the mechanism of action of traditional Chinese medicine and the compatibility rules of prescriptions. Remarkable results. He has published more than 80 papers in core journals at home and abroad, of which more than 40 have been included in SCI and EI. He has 6 authorized patents and 1 patent pending. He has presided over and shared more than ten scientific research projects from the National Natural Science Foundation, the "863" Program, the Ministry of Education, and Tianjin Municipality. His research results won the 1997 Japanese Ministry of Education, Culture, Sports, Culture, Sports, Science and Technology Award Research A and the 2005 Tianjin Municipal Natural Science Second Prize (No. 2005ZR- 2-011-R1).
Postgraduate training:
Won the first prize of Nankai University’s “Dedication” Award in 2006. Two of the doctoral students he supervised were awarded the title of "Ten Outstanding Nankai University Students" in 2005 and 2006 respectively, and the graduate students he supervised have won the "Outstanding Master's Thesis of Nankai University" and "Outstanding Graduate of Nankai University" awards many times. Three courses are offered for graduate students: "Applications of Physical Chemistry in Living Systems" (Master's students), "Bioelectrochemistry" (Ph.D. students), and "Principles and Technology of Biosensors" (Ph.D. students).
Recruitment majors for master’s and doctoral students: biochemistry and molecular biology, zoology
Representative article directory:
1. Zixia Zhao, Mingqiang Qiao , Feng Yin, Bin Shao, Baoyan Wu, Yanyan Wang, Xinsheng Wang, Xia Qin, Sha Li, Lei Yu, Qiang Chen. Amperometric glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization. Biosensors & Bioelectronics, 2007 , 22: 3021-3027 (SCI, IF 5.061)
2.Baoyan Wu, Shihua Hou, Feng Yin, Zixia Zhao, Yanyan Wang, Xinsheng Wang, Qiang Chen. Amperometric glucose biosensor based on multilayer films via layer-by-layer self-assembly of multi-wall carbon nanotubes, gold nanoparticles and glucose oxidase on the Pt electrode. Biosensors & Bioelectronics, 2007, 22: 2854-2860 (SCI, IF 5.061)
3.Baoyan Wu, Shihua Hou, Feng Yin, Jing Li, Zixia Zhao, Jiadong Huang, Qiang Chen. Amperometric Glucose Biosensor Based on Layer-by-layer Assembly of Multilayer Films Composed of Chitosan, Gold Nanoparticals and Glucose Oxidase Modefied Pt Electrode. Biosensors & Bioelectronics, 2007, 22: 838-844 (SCI, IF 5.061)
4. Haibin Shi, Yu Yang, Jiadong Huang, Zixia Zhao, Xinhua Xu, Jun-ichi Anzai, Tetsuo Osa, Qiang Chen. Amperometric Choline Biosensors Prepared by Layer-by-layer Deposition of Choline Oxidase on the Prussian Blue-Modified Platinum Electrode. Talanta, 2006, 70: 852-858 (SCI, IF 3.374)
5. WU Bao-Yan, LI Jing, HUANG Jia-Dong, Wang Yanyan, Yin Huijun, Chen Keji, CHEN Qiang. Real tim
e kinetic analysis of the interaction between interleukin-1α and soluble interleukin-1 receptor using a resonant mirror biosensor. Analytica Chimica Acta, 2006, 557: 106-110 (SCI, IF 3.186)
Main academic papers
Han Songyan, Liu Dongbo, Huang Liang, Wang Shenqi, Liu Qingping, Chen Qiang. Monitoring adsorption in situ and kinetic studies of low-density lipoprotein onto cholesterol modified dextran using qua. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 26-6 -1166. 2005-1-1
Li Jing, Huang Jiadong, Wu Baoyan, Chen Qiang. Effects of propyl gallate on interaction between TNF-alpha and sTNFR-I using an affinity biosensor. ACTA PHARMACOLOGICA SINICA 26-10- 1212. 2005-1-1
Shi Haibin, Zhao Zixia, Song Zhao, Huang Jiadong, Yang Yu, Chen Qiang. Fabricating of acetylcholine biosensor by a layer-by-layer deposition technique for determining trichlorfon. ELECTROANALYSIS 17-14 -1285. 2005-1-1
Chen Qiang, Han Jun, Shi Haibin, Wu Baoyan, Xu Xinhua. Use of Chitosan for developing layer-by-layer multilayer thin films containing glucose oxidase for biosensor applications. Sensor Letters v 2-n 2-p 102-105. 2005-1-1
Shi Haibin, Song Zhao, Huang Jiadong, Yang Yu, Zhao Zixia, Chen Qiang. Effects of the type of polycation in the coating films prepared by a layer-by-layer deposition technique on the properties of amperometric choline sensors. Sensors and Actuators, B: Chemical v 109-n 2-p 341-347. 2005-1-1
Shi Haibin, Song Zhao , Huang Jiadong, Yang Yu, Zhao Zixia, Chen Qiang. Effects of the type of polycation on the amperometric response of choline biosensors prepared by a layer-by-layer deposition technique. Materials Science
and Engineering C v 25-n 4-p 433-435. 2005-1-1
Wu Baoyan, Xu Xinhua, Shi Haibin, Han Songyan, Song Yan, Huang Liang, Chen Qiang. Effect of cellulose acetate diffusion restricting membrane on the glucose biosensor. Tianjin Daxue Xuebao (Ziran Kexue yu Gongcheng Jishu Ban)/Journal of Tianjin University Science and Technology v 38-n 6-p 513-517. 2005-1-1
Yin Feng ; Zhao Zixia; Wu Baoyan; Wang Xinsheng; Wang Yanyan; Chen Qiang. Glucose biosensor based on layer-by-layer assembly of multi-walled carbon nanotubes and polyallylamine. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 35-7-1021-1024. 2007-1-1
Liu Qiang; Xu Xinhua; Zhang Chunhuai; Chen Qiang. Electrochemical deposition of composite films composed of polyaniline and chitosan for biosensor applications. SENSOR LETTERS 5-2-459-462. 2007-1-1
Zhao Zixia ; Qiao Mingqiang; Yin Feng; Shao Bing; Wu Baoyan; Wang Yanyan; Wang Xinsheng; Qin Xia; Li Sha; Yu Lei; Chen Qiang. Amperometric glucose biosensor based on self-assembly hydrophobin with high efficiency of enzyme utilization. BIOSENSORS amp; BIOELECTRONICS 22-12- 3021-3027. 2007-1-1
Wu Baoyan; Hou Shihua; Yin Feng; Zhao Zixia; Wang Yanyan; Wang Xinsheng; Chen Qiang. Amperometric glucose biosensor based on multilayer films via layer-by-layer self-assembly of multi- wall carbon nanotubes, gold nanoparticles and glucose oxidase on the Pt electrode. BIOSENSORS amp; BIOELECTRONICS 22-12-2854-2860. 2007-1-1
Liu Dongbo; He Bingjun; Han Songyan; Wang Shenqi; Liu Qingping; Jun-ichi, A; Osa, T; Chen Qiang. An adsorption behavior of low-density lipoprotein onto cholesterol-modified dextran studied by a quartz crystal microbalance. MATERIALS SCIENCE amp; ENGINEERING C-BI
OMIMETIC AND SUPRAMOLECULAR SYSTEMS 27-4-665-669. 2007-1-1
Huang Jiadong; Song Zhao; Li Jing; Yang Yu; Shi Haibin; Wu Baoyan; Anzai, JI; Osa, T; Chen Qiang. A highly-sensitive L-lactate blosensor based on sol-gel film combined with multi-walled carbon nanotubes (MWCNTs) modified electrode. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 27-1-29-34. 2007-1- 1
Wu Baoyan; Hou Shihua; Yin Feng; Li Jing; Zhao Zixia; Huang Jiadong; Chen Qiang. Amperometric glucose biosensor based on layer-by-layer assembly of multilayer films composed of chitosan, gold nanoparticles and glucose oxidase modified Pt electrode . BIOSENSORS & BIOELECTRONICS 22-6-838-844. 2007-1-1
Song Zhao; Huang Jiadong; Shi Haibin; Wu Baoyan; Zhao Zixia; Chen Qiang. Highly sensitive choline biosensor based on nanotube modified pt electrode combined with sol-gel immobilization. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 34-7-910-914. 2007-1-1
Li, J; Huang, JD; Wu, BY; Song, Z; Chen, Q . Optical biosensor analysis in studying propyl gallate binding to endothelin-1. SENSOR LETTERS 3-4-296. 2006-1-1
Chen, Q; Huang, JD; Yin, HJ; Chen, KJ; Osa, T. The applications of affinity biosensors: IAsys biosensor and quartz crystal microbalance to the study on interaction between Paeoniae radix 801 and endothelin-1. SENSORS AND ACTUATORS B-CHEMICAL 115-1-116. 2006-1-1
Huang, JD; Yang, Y; Shi, HB; Song, Z; Zhao, ZX; Anzai, J; Osa, T; Chen, Q. Multi-walled carbon nanotubes-based glucose biosensor prepared by a layer- b
y-layer technique. MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS 26-1-113. 2006-1-1
Song, Z; Huang, JD; Wu, BY; Shi, HB; Anzai, JI; Chen, Q. Amperometric aqueous sol-gel biosensor for low-potential stable choline detection at multi-wall carbon nanotube modified platinum electrode. SENSORS AND ACTUATORS B-CHEMICAL 115-2-626. 2006-1-1
Shi, H; Yang, Y; Huang, JD; Zhao, ZX; Xu, XH; Anzai, J; Osa, T; Chen, Q. Amperometric choline biosensors prepared by layer-by-layer deposition of choline oxidase on the Prussian blue-modified platinum electrode. TALANTA 70-4-852. 2006-1-1
Wu, BY; Wang, YY; Li, J; Song, Z; Huang, JD; Wang , ; Ren, GL; Cheng, J; Liu, Q; Li, DG; Chen, Q. Layer by layer self-assembly immobilization of glucose oxidase onto chitosan-graft-polyaniline polymers. JOURNAL OF MATERIALS SCIENCE 41-10-3147. 2006 -1-1
Wu, Bao-Yan; Li, Jing; Huang, Jia-Dong; Wang, Yan-Yan; Yin, Hui-Jun; Chen, Ke-Ji; Chen, Qiang. Real time kinetic analysis of the interaction between interleukin-1α and soluble interleukin-1 receptor I using a resonant mirror biosensor. Analytica Chimica Acta v 557-n 1-2-p 106-110. 2006-1-1
Wu, Baoyan; Li, Jing; Shi, Haibin; Huang, Jiadong;
Anzai, Junichi; Osa, Tetsuo; Chen, Qiang. Ferrocene-mediated anti-interfering glucose biosensor based on glutin and cellulose acetate. High Technology Letters v 12-n 3-p 263-266. 2006-1-1
Yanyan Wang, Xinsheng Wang, Baoyan Wu, Zixia Zhao, Feng Yin, Sha Li, Xia Qin, Qiang Chen. Dispersion of single-walled carbon nanotubes in poly(diallyldimethylammonium chloride) for prepara. Sensors and Actuators B
Li Sha, Wang Yanyan, Zhao Zixia, Qin Xia, Wang Xinsheng, Wu Baoyan and Chen Qiang. Preparation of high-performance ethanol biosensors based on nanomaterials and polyelectrolytes. Analytical Chemistry 36-2-227-230. 2008-2-1
Qin Xia Wang Yanyan Zhao Zixia Wang Xinsheng Li Sha Yu Min Huang Nan Miao Zhiying Chen Qiang. Preparation of choline biosensor based on multi-walled carbon nanotubes by layer-by-layer self-assembly. Analytical Chemistry 36-6-827-830. 2008-6-1
Bao-Yan Wu, Shi-Hua Hou, Liang Huang, Feng Yin, Zi-Xia Zhao, Jun-Ichi Anzai, Qiang Chen. Oriented immobilization of immunoglobulin G onto the cuvette surface of the resonant mirror biosenso. Materials Science and Engineering C 28-7-1065-1069. 2008-8-1
Jiadong Huang, Jing Li, Yu Yang, Xinsheng Wang, Baoyan Wu, Qiang Chen. Development of an amperometric L-lactate biosensor based on L-lactate oxidase immobilized through silica sol-gel film on multi-walled carbon nanotubes/platinum nanoparticle modified glassy carbon electrode. Materials Science and Engineering C 28-7-1070-1075. 2008-8-1
Bao-Yan Wu, Shi-Hua Hou, Min Yu, Xia Qin, Sha Li, Qiang Chen. Layer-by-layer assemblies of chitosan/multi-wall carbon nanotubes and glucose oxidase for amperometric glucose biosensor applications. Materials
Science and Engineering C 29-1-346-349. 2009-1-1
Yu Min, Wang Huicai, Qin Xia, Wang Xinsheng, Hao Baoyan, Chen Qiang. Nanosilver/cysteine ??modified glucose biology Research on sensors. Sensors and Microsystems 27-10-24-26. 2008-10-1
Xia Qin, Huicai Wang, Xinsheng Wang, Sha Li, Zhiying Miao, Nan Huang, Qiang Chen. Amperometriccholinebiosensorsbased on multi-wallcarbonnanotubes and layer-by-layer assembly of multilayer films composed of Poly(diallyldimethylammonium chloride) and choline oxidase . Materials Science and Engineering: C
Zi-Xia Zhao, Hui-CaiWang, Xia Qin, Xin-ShengWang, Ming-Qiang Qiao, Jun-ichi Anzaib, Qiang Chen. Self-assembled film of hydrophobins on gold surface and its application to electrochemical biosensing. Colloids and Surfaces B: Biointerfaces
Wei Zhao, Huicai Wang, Xia Qin, Xinsheng Wang, Zixia Zhao, Zhiying Miao, Lili Chen, Miaomiao Shan, Yuxin Fang, Qiang Chen. A novel nonenzymatic hydrogen peroxide sensor based on multi-wall carbon nanotube/silver nanoparticle nanohybrids modified gold electrode. Talanta
HuicaiWang, XinshengWang, Xiaoqing Zhang, Xia Qin, Zixia Zhao, Zhiying Miao, Nan Huang, Qiang Chen. A novel glucose biosensor based on the immobilization of glucose oxidase onto gold nanoparticles-modified Pb nanowires. Biosensors and Bioelectronics
Sha Li, Yanyan Wang, Zixia Zhao, Xia Qin, Xinsheng Wang, Min Yu, Zhiying Miao, Baoyan Wu, Qiang Chen. Amperometric Ethanol Biosensor Based on Layer-by-Layer Deposition of Alc
ohol Oxidase on the Platinum. Sensor letters
Xia Qin, Huicai Wang, Xinsheng Wang, Zhiying Miao, Lili Chen, Wei Zhao, Miaomiao Shan, Qiang Chen. Amperometric biosensors based on gold nanoparticles-decorated multiwalled carbon nanotubes poly(diallyldimethylammonium chloride) biocomposite for the determination of choline. Sensors and Actuators B
Chen Lili, Wang Huicai, Qin Xia, Wang Xinsheng, Zhao Zixia, Miao Zhiying, Zhao Wei, Shan Miaomiao, Chen Qiang. Layer-by-layer self-assembly Technological preparation of PDDA-multiwalled carbon nanotubes-choline biosensors. Analytical Chemistry
Zixia Zhao, Qiang Chen, Jun-ichi ANZAI. Horseradish peroxidase microcapsules based on layer-by-layer polyelectrolyte deposition. Journal of Environmental Sciences 21- supplement 1-
Yanyan Wang, Qiang Chen, Xiangqun Zeng. Potentiometric biosensor for studying hydroquinone cytotoxicity in vitro. Biosensors and Bioelectronics