Furosemide, furosemide, furosemide, furosemide, furosemide, furosemide, furosemide, furosemide.
A diuretic with strong pharmacological action and use acts on the ascending branch of Heinz loop.
indicate
Clinically, it is used to treat cardiogenic edema, renal edema, ascites due to liver cirrhosis, peripheral edema caused by dysfunction or vascular disorder, and can promote the discharge of upper urinary calculi. Its diuretic effect is rapid and strong, and it is used for severe patients who are ineffective in other diuretics. Because of the obvious loss of water and electrolyte, it is not suitable for routine use. Intravenous administration (20 ~ 80 mg) can treat pulmonary edema and brain edema. Drug poisoning can be used to accelerate the excretion of poisons.
Dose usage
1. intramuscular injection or intravenous injection: 20mg each time, every other day 1 time, and every other day 1 ~ 2 times if necessary. The daily dose 1 can be increased to 120mg as required. Intravenous injection must be slow and should not be mixed with other drugs. Children use it less. 2. Oral administration: 40mg daily at the beginning, and then it can be increased to 80 ~ 120 mg daily as needed. When the daily dose exceeds 40mg, it can be taken every 4 hours 1 time. Children's oral dose starts at 1 ~ 2 mg per kilogram of body weight, and then increases as appropriate. After long-term administration (7 ~ 10 day), the diuretic effect disappears, and those who need long-term application should take intermittent therapy: administration 1 ~ 3 days, and drug withdrawal for 2 ~ 4 days.
Matters needing attention
1. Adverse reactions such as mild nausea, diarrhea, drug eruption, itching and blurred vision may occur, and sometimes standing dizziness, fatigue, muscle spasm and thirst may occur. A few patients have leukopenia, while others have thrombocytopenia, erythema multiforme and orthostatic hypotension. Long-term application can cause gastric ulcer and duodenal ulcer. 2. Because it can reduce uric acid excretion, repeated application can produce hyperuricemia, and individual patients can produce acute gout after long-term application. 3. Diabetes patients can raise blood sugar after application; Although its hypoglycemic effect is far weaker than thiazide diuretics, it may still increase blood sugar when combined with hypoglycemic drugs. 4. Because diuresis is rapid and powerful, we should pay attention to master the initial dose to prevent dehydration and electrolyte imbalance caused by excessive diuresis. 5. After taking it, hepatitis patients are prone to hepatic coma due to excessive loss of electrolytes (especially potassium ions). 6. When a large number of drugs are used for a long time, attention should be paid to checking the electrolyte concentration in the blood. Patients with intractable edema are particularly prone to hypokalemia. When using digitalis or steroid hormones that secrete potassium at the same time, attention should be paid to supplementing potassium salt. 7. At the same time of dehydration, the reversible blood urea nitrogen level can be increased. If the creatinine level is not significantly increased and the renal function is not impaired, you can continue to use this product. 8. After using 1 month, the levels of serum electrolyte, carbon dioxide and blood urea nitrogen should be checked regularly. Like other diuretics, when the treatment of progressive renal disease leads to the increase of serum urea nitrogen and oliguria, the drug should be stopped immediately. 9. It can enhance the effect of antihypertensive drugs, so the dosage of antihypertensive drugs should be appropriately reduced when combined with drugs. 10. Because this product is a sulfonamide compound with a similar structure to chlorothiazide, it can reduce the arterial response to pressor amine (such as norepinephrine) and increase the muscle relaxation and paralysis of tubocurarine, so the operation should be stopped on 1 week. 1 1. Hypokalemia, excessive use of digitalis and hepatic coma are prohibited. Use with caution in patients with advanced cirrhosis. 12. hearing loss or temporary deafness may occur if a large dose of intravenous injection is too fast. Compatibility with aminoglycoside antibiotics is more likely to lead to hearing loss.
Specification injection: 20mg(2ml) each. Pills: 20 mg, 40 mg each.