The physical examination of pepsin inhibitor showed that the ratio of pepsinogen 1 was low, while that of other normal pepsinogens 1 decreased gradually. What's the problem?

Hello! Pepsinogen (PG) is the precursor of pepsin secreted by gastric glands in gastric mucosa, which can be divided into two subtypes: pepsinogen I (PGI) and pepsinogen II (PGII). Under normal circumstances, about 1% enters the blood circulation through gastric mucosal capillaries, and serum PG is a reliable biomarker to reflect the functional status of gastric mucosa. Generally speaking, an increase in PG indicates gastric mucosal damage or hyperacidity, while a decrease in PG indicates gastric mucosal atrophy or hyperacidity. Your physical examination results suggest that PGI is low and PGI/PGII ratio is also low, suggesting that gastric mucosa may shrink to some extent. It is suggested to do gastroscopy immediately to make a clear diagnosis. thank you