The current main research areas are radiogene therapy and signal transduction of nasopharyngeal carcinoma. After returning to China in 2003, he cooperated with the school's dominant disciplines, clinical and foreign countries to carry out relevant research work. Cooperated with Dr. MH-Lee, applied for and received five funds to explore the effects and mechanisms of 14-3-3σ and p27 genes in cancer treatment and radiation tolerance, and completed adenovirus-mediated 14-3-3σ gene transfer. To explore the effect and mechanism of dyeing in the treatment of NPC, and at the same time prove that 14-3-3σ negatively regulates Akt and inhibits the proliferation and tumorigenicity of Akt-overexpressing cells. He has applied for a Chinese invention patent (application number 200510102126.0) and published 1 SCI paper [Mol Cancer Ther (IF: 5.242)] as the first author. At the same time, we cooperated with Professors Huang Wenlin and Xia Yunfei from the National Key Laboratory of Oncology in South China, and participated as the first major member in the National Natural Science Foundation of China (NYD-SP8) as a new prognostic indicator for radiotherapy for nasopharyngeal carcinoma (30570543) chaired by Professor Xia Yunfei. 2005-2008), and participated in the "973 Plan" chaired by Professor Huang Wenlin and the key breakthrough projects in key areas of Guangdong Province, focusing on applied basic research on radioactive gene therapy, and participated in the publication of 1 SCI paper [Cell Biology International (IF: 1.019)].
We are now using a climbing intermittent high-dose X-ray induction model to compare radiation-resistant NPC cells with the same genetic background and different backgrounds, and plan to use high-throughput detection methods to screen CNE-2R and parental CNE-2. differences, and explore their interrelationships, aiming to obtain information or evidence on the post-transcriptional regulation of differential proteins by miRNAs, to provide scientific information for elucidating the mechanism of radioresistance in nasopharyngeal carcinoma, mining sensitive indicators for evaluating radioresistance, and establishing new targets for reversing radioresistance. in accordance with.