The main research areas are molecular biology and genetic engineering of cytokines. Discovered a new cytokine that can specifically stimulate liver cell proliferation and liver regeneration, namely human hepatopoietin (HPO), published its cDNA sequence for the first time in the world, and took the lead in developing recombinant human HPO, revealing for the first time that it exists in primary livers. HPO high-affinity specific receptors and HPO two signal transduction pathways on the membrane of cells or liver cancer cells. Carry out large-scale human fetal liver cDNA cloning and sequencing, establish a large-scale and systematic gene expression profile, and discover gene groups related to liver development, differentiation, carcinogenesis, and hematopoietic system development. He proposed regular understandings such as "development-related evolution" of growth factors, "co-evolution" of cell active factors and receptors, "coordinated evolution" of mRNA coding and non-coding regions, and "molecular decelerated evolution" in phylogeny. And some experimental verifications were carried out.
1 Discovered "development-related evolution of cell active factors", "co-evolution of interacting molecules", "coordinated evolution of mRNA coding and non-coding regions" and "decelerated molecular evolution in species evolution" and other regular phenomena;
2 Discover and clone hepatopoietin, reveal its gene regulation mechanism, develop its recombinant product, and discover its receptor and its two signal transduction pathways;
< p>3 Revealed the transcriptome and proteome of human fetal liver and adult liver, and discovered more than 500 new genes and new proteins;4 Discovered susceptibility genes for common malignant tumors and chronic hepatitis in China10 Yu Zhong; initiated and led the "Liver Proteome Project", the first human tissue and organ project. This was also the first time that China led a large-scale international cooperation project, and was recognized by internationally renowned magazines such as Nature, Science, and Nature Biotechnology;
5 Elected as an academician of the Chinese Academy of Sciences in 2001; elected as an academician of the Academy of Sciences of Developing Countries in 2005; Representative of the 18th National Congress of the Communist Party of China and alternate member of the 18th Central Committee;
International Human *** Co-Executive Chairman of the Liver Proteome Project;
Director of the International Human Proteome Organization;
Vice Chairman of the Asia-Pacific Human Proteome Organization;
Chinese Medicine Vice President of the Society;
Vice Chairman of the Chinese Genetics Society;
Vice Chairman of the Chinese Biophysical Society;
Vice Chairman of the Beijing Association for Science and Technology;
Vice Chairman of the Beijing Association for Science and Technology;
Vice Chairman of the Chinese Biophysical Society; p>
Chairman of the Chinese Human Proteome Organization;
Member of the Discipline Review Group of the State Council Degree Evaluation Committee;
Member of the National “863” Program Expert Group in the Field of Biological and Medical Technology;< /p>
Deputy leader of the National Medium and Long-term "Protein Science Major Research Plan" expert group;
Director of the China Postdoctoral Foundation;
Deputy director of the Military Medical Science and Technology Committee Member;
Chairman of the Military Biological Hazard Prevention Professional Committee;
Part-time member of the General Assembly Science and Technology Committee and leader of the Military Biotechnology Professional Demonstration Group;
Military Medicine President of the Academy of Sciences;
Chairman of Beijing Proteomics Research Center;
Director of the State Key Laboratory of Proteomics;
Senior Editor of Proteomics and Proteomics-Clinical Application ;
Executive editor of Journal of Proteomics & Bioinformatics;
Editorial board member of Journal of Proteome Research;
Mainly engaged in genomics, proteomics, bioinformatics and Systems biology research. Major general, researcher, first-level professional technology, doctoral supervisor.
He has successively served as an intern researcher, assistant researcher, associate researcher, researcher, deputy director, director, deputy director, director of the Academy of Military Medical Sciences, director of the Chinese People's Liberation Army Center for Disease Control and Prevention, and Beijing Proteome Research Center First Director.
Won the second prize of the National Natural Science Award in 2005 and 2006;
won the second prize of the National Science and Technology Progress Award in 1999 and 2000;
won the first prize of the Military Science and Technology Progress Award in 1997 and 2005;
Won the first prize of Beijing Science and Technology Award in 2002, 2003 and 2005;
In 1993, he was named "National Young and Middle-aged Medical Science and Technology Star" and "China Youth Science and Technology Award" ";
In 1994, he was named "National Youth Science and Technology Model";
In 1996, he won the "National Science Fund for Outstanding Youth";
In 1998, he won the " National Qiushi Outstanding Youth Practical Engineering Award", and was rated as the "Science and Technology Gold Star" of the General Logistics Department; in 1999, he was approved as a "National Young and Middle-aged Expert with Outstanding Contributions";
In 2002, he was named "China Young Scientist" and awarded China's "May 4th" Youth Medal;
In 2003, he won the "Ho Leung Ho Lee Foundation Science and Technology Progress Award" and was rated as "Outstanding in the Army" Graduate Advisor";
In 2004, he was awarded the "Research Contribution Award" by the International Human Proteome Organization;
In 2005, he was awarded the "Military Professional and Technical Major Contribution Award";
In 2006, the Army Key Laboratory of Proteomics and Genomics, which he led (as laboratory director), won the "Military Science and Technology Innovation Group Award";
In 2009, it was awarded by the International Proteome Forum "Outstanding Achievement Award";
In 2011, he was awarded the "Outstanding Service Award" by the International Human Proteome Organization;
Won 7 Chinese invention patents, 1 national new drug certificate, and the United States Invention 1 patent.
He has edited/translated more than ten monographs. He has published more than 200 papers in core international journals such as Science, Nature Genetics, Nature Cell Biology, Nature Biotechnology, Nature Methods, Nature Protocols, and PNAS. Chief editor of "Bioinformatics - Methods and Practice", "Hematopoiesis Regulation", "Theory and Technology of Proteomics", "Severe Acute Respiratory Syndrome (SARS)", etc.
Participated in the editing of "Life "Years and Dreams", "Genome Science and Human Diseases", "Protein Molecular Structure", "Medical Molecular Biology".