How to find and develop methoxyacrylate fungicides?

Methoxyacrylate bactericide is a bionic bactericide, which is a landmark agricultural bactericide after benzimidazole and triazole. After nearly 20 years of development, it has become a very important fungicide, accounting for a lot of fungicides with sales of hundreds of millions of dollars. The lead compound of this kind of bactericide: strobilurin A (strobilurin? A) and strobilurin b (strobilurin? B) It was originally from Strobilurus? Tenacellus was isolated from the culture medium and also translated into Eperythrozoon coccidia. This IBWF is the German Institute of Biotechnology and Medicine, located in Kaiserslautern University, Germany. In fact, this strobilurin. A and Musikek et al. 1969 are from Odysseus mold (Oudemansiella? The mucin isolated from mucin is very similar, and this mucin has antifungal activity. Strobilurin? The infrared spectrum, ultraviolet spectrum and elemental composition of A and mucin are the same, but the optical rotation is different. Later, Lainke and others further studied Odysseus (Oudemansiella? Mucin) and isolate strobilurin? Answer? In addition, we also got the crystal of Oda mushroom.